Direct antiapoptotic effects of growth hormone are mediated by PI3K/Akt pathway in the chicken bursa of Fabricius

Highlights • GH has a direct anti-apoptotic effect on chicken cultured bursal B lymphocytes. • Direct anti-apoptotic effects of GH are mediated by PI3K/Akt pathway. • Bcl-2 expression is stimulated by GH in cultured B lymphocytes. • IGF-I production in cultured B lymphocytes is GH-independent....

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Veröffentlicht in:	General and comparative endocrinology 2015-12, Vol.224, p.148-159
Hauptverfasser:	Luna-Acosta, José Luis, Alba-Betancourt, Clara, Martínez-Moreno, Carlos G, Ramírez, Candy, Carranza, Martha, Luna, Maricela, Arámburo, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - metabolism Blotting, Western Bursa of Fabricius Bursa of Fabricius - cytology Bursa of Fabricius - drug effects Bursa of Fabricius - metabolism Caspase 3 - metabolism Cells, Cultured Chickens - metabolism Endocrinology & Metabolism Enzyme-Linked Immunosorbent Assay Growth hormone Growth Hormone - pharmacology IGF-I Immunoenzyme Techniques In Situ Nick-End Labeling Insulin-Like Growth Factor I - metabolism Male Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects PI3K/Akt pathway Signal Transduction - drug effects Wortmannin
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Zusammenfassung:	Highlights • GH has a direct anti-apoptotic effect on chicken cultured bursal B lymphocytes. • Direct anti-apoptotic effects of GH are mediated by PI3K/Akt pathway. • Bcl-2 expression is stimulated by GH in cultured B lymphocytes. • IGF-I production in cultured B lymphocytes is GH-independent.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.07.010