CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients

Highlights • CXCR7, CXCR4, CXCL12 , CXCL14 and CXCR4 isoforms are expressed in Ewing sarcoma. • CXCR4-1/CXCR4-2 isoform ratio and CXCL14 and CXCR7 associate with improved survival. • CXCR4 and CXCL12 mRNA expression are not associated with survival in Ewing sarcoma. • Factors mitigating CXCR4 activa...

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Veröffentlicht in:	European journal of cancer (1990) 2015-11, Vol.51 (17), p.2624-2633
Hauptverfasser:	Sand, L.G.L, Scotlandi, K, Berghuis, D, Snaar-Jagalska, B.E, Picci, P, Schmidt, T, Szuhai, K, Hogendoorn, P.C.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biomarker Bone Neoplasms - genetics Bone Neoplasms - pathology Cell Line, Tumor Chemokine CXCL12 - genetics Chemokines, CXC - genetics Child Child, Preschool Disease-Free Survival Female Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Male Middle Aged Molecular targeted therapy Neoplasm Metastasis Protein Isoforms - genetics Receptors, CXCR - genetics Receptors, CXCR4 - genetics Reverse Transcriptase Polymerase Chain Reaction RNA Splicing Sarcoma, Ewing - genetics Sarcoma, Ewing - pathology Signal Transduction - genetics Splice variant Tumour microenvironment Young Adult
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Zusammenfassung:	Highlights • CXCR7, CXCR4, CXCL12 , CXCL14 and CXCR4 isoforms are expressed in Ewing sarcoma. • CXCR4-1/CXCR4-2 isoform ratio and CXCL14 and CXCR7 associate with improved survival. • CXCR4 and CXCL12 mRNA expression are not associated with survival in Ewing sarcoma. • Factors mitigating CXCR4 activation predict better clinical outcomes.
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2015.08.020