Single organ metastatic disease and local disease status, prognostic factors for overall survival in stage IV non-small cell lung cancer: Results from a population-based study

Highlights • OS significantly longer in single organ metastatic disease compared to 2 or ⩾3 organs. • Single organ metastases also prognostic in subgroup of18 FDG-PET-staged patients. • Single organ metastases also prognostic in patients receiving anticancer treatment. • In single organ metastases,...

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Veröffentlicht in:	European journal of cancer (1990) 2015-11, Vol.51 (17), p.2534-2544
Hauptverfasser:	Hendriks, L.E, Derks, J.L, Postmus, P.E, Damhuis, R.A, Houben, R.M.A, Troost, E.G.C, Hochstenbag, M.M, Smit, E.F, Dingemans, A.-M.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Aged Bone Neoplasms - secondary Brain Neoplasms - secondary Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - pathology Female Fluorodeoxyglucose F18 Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Liver Neoplasms - secondary Local disease status Lung Neoplasms - pathology Lymphatic Metastasis Male Metastases Middle Aged Multimodal Imaging - methods Multimodal Imaging - statistics & numerical data Neoplasm Recurrence, Local Neoplasm Staging Non-small cell lung cancer Positron-Emission Tomography Prognosis Proportional Hazards Models Stage IV Tomography, X-Ray Computed
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Zusammenfassung:	Highlights • OS significantly longer in single organ metastatic disease compared to 2 or ⩾3 organs. • Single organ metastases also prognostic in subgroup of18 FDG-PET-staged patients. • Single organ metastases also prognostic in patients receiving anticancer treatment. • In single organ metastases, low local disease (i.e. T1–2 and N0–1) best prognosis.
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2015.08.008