Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes

Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth. Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional vol...

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Veröffentlicht in:	The Journal of pediatrics 2015-12, Vol.167 (6), p.1259-1263.e1
Hauptverfasser:	von Rhein, Michael, MD, Buchmann, Andreas, PhD, Hagmann, Cornelia, MD, PhD, Dave, Hitendu, MD, Bernet, Vera, MD, Scheer, Ianina, MD, Knirsch, Walter, MD, Latal, Beatrice, MD, MPH
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - growth & development Cohort Studies Developmental Disabilities - etiology Female Heart Defects, Congenital - complications Heart Defects, Congenital - surgery Humans Infant Infant, Newborn Magnetic Resonance Imaging - methods Male Pediatrics Prospective Studies Switzerland
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Zusammenfassung:	Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth. Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions. Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2015.07.006