Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry
Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodbor...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 2015-12, Vol.61 (12), p.e58-e61 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e61 |
|---|---|
| container_issue | 12 |
| container_start_page | e58 |
| container_title | Clinical infectious diseases |
| container_volume | 61 |
| creator | Rosen, Osnat Feldberg, Liron Gura, Sigalit Brosh-Nissimov, Tal Guri, Alex Zimhony, Oren Shapiro, Eli Beth-Din, Adi Stein, Dana Ozeri, Eyal Barnea, Ada Turgeman, Amram Ben David, Alon Schwartz, Arieh Elhanany, Eytan Diamant, Eran Yitzhaki, Shmuel Zichel, Ran |
| description | Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure. |
| doi_str_mv | 10.1093/cid/civ861 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1736681189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1736681189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-8bceaee33fd506c82ed75821f9e49efcc2a1af49f89dc5797cccf6bcc43792523</originalsourceid><addsrcrecordid>eNpdkF1LwzAUhoMobk5v_AFS8EbEatI0bXKpc37AhqjzuqTpiWS0S01aof_ejE0vvDi85-Lh5ZwHoVOCrwkW9EaZKsw3z8geGhNG8zhjguyHHTMep5zyETryfoUxIRyzQzRKsjTBHOMxep1JVw9X0RvIOl6aBqIFVEbJOro38nNtvfGR1dGd7fra-CYqh2i2rmwLbWcq6SFeSO-j9xZU52wDnRuO0YGWtYeTXU7Qx8NsOX2K5y-Pz9PbeawoYV3MSwUSgFJdMZwpnkCVM54QLSAVoJVKJJE6FZqLSrFc5EopnZVKpTQXCUvoBF1se1tnv3rwXdEYr6Cu5Rps7wuS0yzj4WMR0PN_6Mr2bh2u21A89CUEB-pySylnvXegi9aZRrqhILjYiC6C6GIrOsBnu8q-bKD6Q3_N0h-cEHnW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1738792210</pqid></control><display><type>article</type><title>Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Rosen, Osnat ; Feldberg, Liron ; Gura, Sigalit ; Brosh-Nissimov, Tal ; Guri, Alex ; Zimhony, Oren ; Shapiro, Eli ; Beth-Din, Adi ; Stein, Dana ; Ozeri, Eyal ; Barnea, Ada ; Turgeman, Amram ; Ben David, Alon ; Schwartz, Arieh ; Elhanany, Eytan ; Diamant, Eran ; Yitzhaki, Shmuel ; Zichel, Ran</creator><creatorcontrib>Rosen, Osnat ; Feldberg, Liron ; Gura, Sigalit ; Brosh-Nissimov, Tal ; Guri, Alex ; Zimhony, Oren ; Shapiro, Eli ; Beth-Din, Adi ; Stein, Dana ; Ozeri, Eyal ; Barnea, Ada ; Turgeman, Amram ; Ben David, Alon ; Schwartz, Arieh ; Elhanany, Eytan ; Diamant, Eran ; Yitzhaki, Shmuel ; Zichel, Ran</creatorcontrib><description>Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/civ861</identifier><identifier>PMID: 26420800</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Antitoxins - administration & dosage ; Botulism ; Botulism - diagnosis ; Botulism - therapy ; Early Diagnosis ; Endopeptidases - blood ; Humans ; Infant ; Male ; Mass spectrometry ; Mass Spectrometry - methods ; Medical diagnosis ; Serum - chemistry ; Time Factors ; Toxins ; Treatment Outcome</subject><ispartof>Clinical infectious diseases, 2015-12, Vol.61 (12), p.e58-e61</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Dec 15, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-8bceaee33fd506c82ed75821f9e49efcc2a1af49f89dc5797cccf6bcc43792523</citedby><cites>FETCH-LOGICAL-c315t-8bceaee33fd506c82ed75821f9e49efcc2a1af49f89dc5797cccf6bcc43792523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26420800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosen, Osnat</creatorcontrib><creatorcontrib>Feldberg, Liron</creatorcontrib><creatorcontrib>Gura, Sigalit</creatorcontrib><creatorcontrib>Brosh-Nissimov, Tal</creatorcontrib><creatorcontrib>Guri, Alex</creatorcontrib><creatorcontrib>Zimhony, Oren</creatorcontrib><creatorcontrib>Shapiro, Eli</creatorcontrib><creatorcontrib>Beth-Din, Adi</creatorcontrib><creatorcontrib>Stein, Dana</creatorcontrib><creatorcontrib>Ozeri, Eyal</creatorcontrib><creatorcontrib>Barnea, Ada</creatorcontrib><creatorcontrib>Turgeman, Amram</creatorcontrib><creatorcontrib>Ben David, Alon</creatorcontrib><creatorcontrib>Schwartz, Arieh</creatorcontrib><creatorcontrib>Elhanany, Eytan</creatorcontrib><creatorcontrib>Diamant, Eran</creatorcontrib><creatorcontrib>Yitzhaki, Shmuel</creatorcontrib><creatorcontrib>Zichel, Ran</creatorcontrib><title>Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.</description><subject>Antitoxins - administration & dosage</subject><subject>Botulism</subject><subject>Botulism - diagnosis</subject><subject>Botulism - therapy</subject><subject>Early Diagnosis</subject><subject>Endopeptidases - blood</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Medical diagnosis</subject><subject>Serum - chemistry</subject><subject>Time Factors</subject><subject>Toxins</subject><subject>Treatment Outcome</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkF1LwzAUhoMobk5v_AFS8EbEatI0bXKpc37AhqjzuqTpiWS0S01aof_ejE0vvDi85-Lh5ZwHoVOCrwkW9EaZKsw3z8geGhNG8zhjguyHHTMep5zyETryfoUxIRyzQzRKsjTBHOMxep1JVw9X0RvIOl6aBqIFVEbJOro38nNtvfGR1dGd7fra-CYqh2i2rmwLbWcq6SFeSO-j9xZU52wDnRuO0YGWtYeTXU7Qx8NsOX2K5y-Pz9PbeawoYV3MSwUSgFJdMZwpnkCVM54QLSAVoJVKJJE6FZqLSrFc5EopnZVKpTQXCUvoBF1se1tnv3rwXdEYr6Cu5Rps7wuS0yzj4WMR0PN_6Mr2bh2u21A89CUEB-pySylnvXegi9aZRrqhILjYiC6C6GIrOsBnu8q-bKD6Q3_N0h-cEHnW</recordid><startdate>20151215</startdate><enddate>20151215</enddate><creator>Rosen, Osnat</creator><creator>Feldberg, Liron</creator><creator>Gura, Sigalit</creator><creator>Brosh-Nissimov, Tal</creator><creator>Guri, Alex</creator><creator>Zimhony, Oren</creator><creator>Shapiro, Eli</creator><creator>Beth-Din, Adi</creator><creator>Stein, Dana</creator><creator>Ozeri, Eyal</creator><creator>Barnea, Ada</creator><creator>Turgeman, Amram</creator><creator>Ben David, Alon</creator><creator>Schwartz, Arieh</creator><creator>Elhanany, Eytan</creator><creator>Diamant, Eran</creator><creator>Yitzhaki, Shmuel</creator><creator>Zichel, Ran</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20151215</creationdate><title>Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry</title><author>Rosen, Osnat ; Feldberg, Liron ; Gura, Sigalit ; Brosh-Nissimov, Tal ; Guri, Alex ; Zimhony, Oren ; Shapiro, Eli ; Beth-Din, Adi ; Stein, Dana ; Ozeri, Eyal ; Barnea, Ada ; Turgeman, Amram ; Ben David, Alon ; Schwartz, Arieh ; Elhanany, Eytan ; Diamant, Eran ; Yitzhaki, Shmuel ; Zichel, Ran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-8bceaee33fd506c82ed75821f9e49efcc2a1af49f89dc5797cccf6bcc43792523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antitoxins - administration & dosage</topic><topic>Botulism</topic><topic>Botulism - diagnosis</topic><topic>Botulism - therapy</topic><topic>Early Diagnosis</topic><topic>Endopeptidases - blood</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Medical diagnosis</topic><topic>Serum - chemistry</topic><topic>Time Factors</topic><topic>Toxins</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosen, Osnat</creatorcontrib><creatorcontrib>Feldberg, Liron</creatorcontrib><creatorcontrib>Gura, Sigalit</creatorcontrib><creatorcontrib>Brosh-Nissimov, Tal</creatorcontrib><creatorcontrib>Guri, Alex</creatorcontrib><creatorcontrib>Zimhony, Oren</creatorcontrib><creatorcontrib>Shapiro, Eli</creatorcontrib><creatorcontrib>Beth-Din, Adi</creatorcontrib><creatorcontrib>Stein, Dana</creatorcontrib><creatorcontrib>Ozeri, Eyal</creatorcontrib><creatorcontrib>Barnea, Ada</creatorcontrib><creatorcontrib>Turgeman, Amram</creatorcontrib><creatorcontrib>Ben David, Alon</creatorcontrib><creatorcontrib>Schwartz, Arieh</creatorcontrib><creatorcontrib>Elhanany, Eytan</creatorcontrib><creatorcontrib>Diamant, Eran</creatorcontrib><creatorcontrib>Yitzhaki, Shmuel</creatorcontrib><creatorcontrib>Zichel, Ran</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosen, Osnat</au><au>Feldberg, Liron</au><au>Gura, Sigalit</au><au>Brosh-Nissimov, Tal</au><au>Guri, Alex</au><au>Zimhony, Oren</au><au>Shapiro, Eli</au><au>Beth-Din, Adi</au><au>Stein, Dana</au><au>Ozeri, Eyal</au><au>Barnea, Ada</au><au>Turgeman, Amram</au><au>Ben David, Alon</au><au>Schwartz, Arieh</au><au>Elhanany, Eytan</au><au>Diamant, Eran</au><au>Yitzhaki, Shmuel</au><au>Zichel, Ran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2015-12-15</date><risdate>2015</risdate><volume>61</volume><issue>12</issue><spage>e58</spage><epage>e61</epage><pages>e58-e61</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>26420800</pmid><doi>10.1093/cid/civ861</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2015-12, Vol.61 (12), p.e58-e61 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1736681189 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antitoxins - administration & dosage Botulism Botulism - diagnosis Botulism - therapy Early Diagnosis Endopeptidases - blood Humans Infant Male Mass spectrometry Mass Spectrometry - methods Medical diagnosis Serum - chemistry Time Factors Toxins Treatment Outcome |
| title | Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T21%3A48%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early,%20Real-Time%20Medical%20Diagnosis%20of%20Botulism%20by%20Endopeptidase-Mass%20Spectrometry&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Rosen,%20Osnat&rft.date=2015-12-15&rft.volume=61&rft.issue=12&rft.spage=e58&rft.epage=e61&rft.pages=e58-e61&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093/cid/civ861&rft_dat=%3Cproquest_cross%3E1736681189%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1738792210&rft_id=info:pmid/26420800&rfr_iscdi=true |