Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry

Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry

Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodbor...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical infectious diseases 2015-12, Vol.61 (12), p.e58-e61
Hauptverfasser: Rosen, Osnat, Feldberg, Liron, Gura, Sigalit, Brosh-Nissimov, Tal, Guri, Alex, Zimhony, Oren, Shapiro, Eli, Beth-Din, Adi, Stein, Dana, Ozeri, Eyal, Barnea, Ada, Turgeman, Amram, Ben David, Alon, Schwartz, Arieh, Elhanany, Eytan, Diamant, Eran, Yitzhaki, Shmuel, Zichel, Ran
Format: Artikel
Sprache:eng
Schlagworte:
Antitoxins - administration & dosage
Botulism
Botulism - diagnosis
Botulism - therapy
Early Diagnosis
Endopeptidases - blood
Humans
Infant
Male
Mass spectrometry
Mass Spectrometry - methods
Medical diagnosis
Serum - chemistry
Time Factors
Toxins
Treatment Outcome
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/civ861