Preserved global histone H4 acetylation linked to ETV6-RUNX1 fusion and PAX5 deletions is associated with favorable outcome in pediatric B-cell progenitor acute lymphoblastic leukemia

Highlights • Global histone H4 acetylation is frequently lost in pediatric BCP-ALL. • Relatively preserved histone H4 acetylation is associated with favorable outcome in BCP-ALL. • Cases with ETV6-RUNX1 fusion gene and PAX5 deletions demonstrated higher histone H4 acetylation.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2015-12, Vol.39 (12), p.1455-1461
Hauptverfasser:	Janczar, K, Janczar, S, Pastorczak, A, Mycko, K, Paige, A.J.W, Zalewska-Szewczyk, B, Wagrowska-Danilewicz, M, Danilewicz, M, Mlynarski, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acute lymphoblastic leukemia Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Child Child, Preschool Chromosomes, Human, Pair 12 - ultrastructure Chromosomes, Human, Pair 21 - ultrastructure Core Binding Factor Alpha 2 Subunit - physiology Disease-Free Survival Epigenesis, Genetic Epigenetics Female Hematology, Oncology and Palliative Medicine Histone acetylation Histones - metabolism Humans Infant Male Multiplex Polymerase Chain Reaction Oncogene Proteins, Fusion - physiology PAX5 Transcription Factor - deficiency PAX5 Transcription Factor - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Prognosis Proportional Hazards Models Protein Processing, Post-Translational Remission Induction Translocation, Genetic Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Global histone H4 acetylation is frequently lost in pediatric BCP-ALL. • Relatively preserved histone H4 acetylation is associated with favorable outcome in BCP-ALL. • Cases with ETV6-RUNX1 fusion gene and PAX5 deletions demonstrated higher histone H4 acetylation.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.10.006