Polymorphisms within beta-catenin encoding gene affect multiple myeloma development and treatment

Highlights • Cereblon and β-catenin are involved in IMiD therapy of multiple myeloma. • One SNP in the cereblon and two SNPs in the β-catenin encoding genes were examined. • The β-catenin rs4533622 SNP was associated with stage of the disease. • Both β-catenin SNPs turned out to be linked to thalido...

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Veröffentlicht in:	Leukemia research 2015-12, Vol.39 (12), p.1462-1466
Hauptverfasser:	Butrym, Aleksandra, Rybka, Justyna, Łacina, Piotr, Gębura, Katarzyna, Frontkiewicz, Diana, Bogunia-Kubik, Katarzyna, Mazur, Grzegorz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use beta Catenin - genetics beta Catenin - physiology Cell Cycle CRBN gene polymorphism CTNNB1 gene polymorphism Cyclophosphamide - administration & dosage Dexamethasone - administration & dosage Female Genotype Hematology, Oncology and Palliative Medicine Humans Immunologic Factors - administration & dosage Immunologic Factors - adverse effects Lenalidomide Male Middle Aged Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - pathology Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neoplasm Staging Neutropenia - chemically induced Peptide Hydrolases - genetics Peptide Hydrolases - physiology Polymorphism, Single Nucleotide Response to immunomodulating therapy Stage of the disease Thalidomide - administration & dosage Thalidomide - analogs & derivatives Wnt Signaling Pathway - drug effects
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Beschreibung
Zusammenfassung:	Highlights • Cereblon and β-catenin are involved in IMiD therapy of multiple myeloma. • One SNP in the cereblon and two SNPs in the β-catenin encoding genes were examined. • The β-catenin rs4533622 SNP was associated with stage of the disease. • Both β-catenin SNPs turned out to be linked to thalidomide treatment.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.10.007