The sequelae of cranial irradiation on human cognition

Cranial irradiation (CI) confers remediation of many CNS anomalies. CI, however, carries risks to cognitive performance. A wealth of data describes such deficits specifically in humans. Risk factors that promote increased susceptibility to cognitive decline have also been identified. This paper disc...

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Veröffentlicht in:	Neuroscience letters 2005-07, Vol.382 (1), p.118-123
1. Verfasser:	Sarkissian, Vahé
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Biological and medical sciences Brain - radiation effects Cognition Cognition - radiation effects Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - psychology Female Fundamental and applied biological sciences. Psychology Humans Male Methotrexate Neurogenesis Pediatric Radiation Radiotherapy - adverse effects Risk Factors Sex Characteristics Vertebrates: nervous system and sense organs
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Zusammenfassung:	Cranial irradiation (CI) confers remediation of many CNS anomalies. CI, however, carries risks to cognitive performance. A wealth of data describes such deficits specifically in humans. Risk factors that promote increased susceptibility to cognitive decline have also been identified. This paper discusses and grades these risk factors, including age, gender, and the inclusion of chemotherapy, that increase the likelihood of pathologic cognitive development in the human population.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2005.02.068