Seasonal split influenza vaccine induced IgE sensitization against influenza vaccine

Highlights • Anaphylaxis was reported after immunization with influenza vaccine in 2011/12. • All patients received split vaccine containing 2-phenoxyethanol as preservative. • IgE antibodies were detected against influenza vaccine materials. • Contributing factors for IgE sensitization were investi...

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Veröffentlicht in:	Vaccine 2015-11, Vol.33 (45), p.6099-6105
Hauptverfasser:	Nakayama, Tetsuo, Kumagai, Takuji, Nishimura, Naoko, Ozaki, Takao, Okafuji, Teruo, Suzuki, Eitaro, Miyata, Akiko, Okada, Kenji, Ihara, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergies Allergy and Immunology Anaphylaxis Anaphylaxis - etiology Antigens Avian flu Child Child, Preschool Disease Outbreaks Ethylene Glycols Female Hemagglutination Inhibition Tests Humans IgE antibody IgG4 antibody Immunity, Innate Immunization Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulins Infant Infant, Newborn Infections Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza B virus - immunology Influenza vaccine Influenza Vaccines - chemistry Influenza Vaccines - immunology Influenza, Human - prevention & control Male Preservatives Preservatives, Pharmaceutical Proteins Seasons Split vaccine Studies Vaccination Vaccines Vaccines, Inactivated - adverse effects Vaccines, Inactivated - immunology
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Beschreibung
Zusammenfassung:	Highlights • Anaphylaxis was reported after immunization with influenza vaccine in 2011/12. • All patients received split vaccine containing 2-phenoxyethanol as preservative. • IgE antibodies were detected against influenza vaccine materials. • Contributing factors for IgE sensitization were investigated. • IgE antibodies against the influenza vaccine increased after immunization. • Young children were more likely to be sensitized.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.05.106