Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)
Highlights • Complement factor H binds to human macrophages via CD11b/CD18 and CD11c/CD18. • Factor H enhances Candida albicans and zymosan induced release of IL-1β and IL-6. • Sap2 of Candida albicans inactivates factor H, CD11b/CD18 and CD11c/CD18.
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| Veröffentlicht in: | Immunology letters 2015-11, Vol.168 (1), p.13-21 |
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| container_title | Immunology letters |
| container_volume | 168 |
| creator | Svoboda, Eliška Schneider, Andrea E Sándor, Noémi Lermann, Ulrich Staib, Peter Kremlitzka, Mariann Bajtay, Zsuzsa Barz, Dagmar Erdei, Anna Józsi, Mihály |
| description | Highlights • Complement factor H binds to human macrophages via CD11b/CD18 and CD11c/CD18. • Factor H enhances Candida albicans and zymosan induced release of IL-1β and IL-6. • Sap2 of Candida albicans inactivates factor H, CD11b/CD18 and CD11c/CD18. |
| doi_str_mv | 10.1016/j.imlet.2015.08.009 |
| format | Article |
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| identifier | ISSN: 0165-2478 |
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| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Allergy and Immunology Aspartic Acid Endopeptidases - immunology Aspartic Acid Endopeptidases - metabolism Blotting, Western Candida albicans Candida albicans - enzymology Candida albicans - immunology Candida albicans - physiology CD11b Antigen - genetics CD11b Antigen - immunology CD11b Antigen - metabolism CD11c Antigen - genetics CD11c Antigen - immunology CD11c Antigen - metabolism CD18 Antigens - genetics CD18 Antigens - immunology CD18 Antigens - metabolism Cell Line, Tumor Cells, Cultured Complement Complement Factor H - immunology Complement Factor H - metabolism CR3 Cytokines - immunology Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Factor H Fungal pathogen Fungal Proteins - immunology Fungal Proteins - metabolism Host-Pathogen Interactions - immunology Humans Immune evasion Integrin alphaXbeta2 - genetics Integrin alphaXbeta2 - immunology Integrin alphaXbeta2 - metabolism Macrophage-1 Antigen - genetics Macrophage-1 Antigen - immunology Macrophage-1 Antigen - metabolism Protease RNA Interference Sap2 |
| title | Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) |
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