Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)

Highlights • Complement factor H binds to human macrophages via CD11b/CD18 and CD11c/CD18. • Factor H enhances Candida albicans and zymosan induced release of IL-1β and IL-6. • Sap2 of Candida albicans inactivates factor H, CD11b/CD18 and CD11c/CD18.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2015-11, Vol.168 (1), p.13-21
Hauptverfasser:	Svoboda, Eliška, Schneider, Andrea E, Sándor, Noémi, Lermann, Ulrich, Staib, Peter, Kremlitzka, Mariann, Bajtay, Zsuzsa, Barz, Dagmar, Erdei, Anna, Józsi, Mihály
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Aspartic Acid Endopeptidases - immunology Aspartic Acid Endopeptidases - metabolism Blotting, Western Candida albicans Candida albicans - enzymology Candida albicans - immunology Candida albicans - physiology CD11b Antigen - genetics CD11b Antigen - immunology CD11b Antigen - metabolism CD11c Antigen - genetics CD11c Antigen - immunology CD11c Antigen - metabolism CD18 Antigens - genetics CD18 Antigens - immunology CD18 Antigens - metabolism Cell Line, Tumor Cells, Cultured Complement Complement Factor H - immunology Complement Factor H - metabolism CR3 Cytokines - immunology Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Factor H Fungal pathogen Fungal Proteins - immunology Fungal Proteins - metabolism Host-Pathogen Interactions - immunology Humans Immune evasion Integrin alphaXbeta2 - genetics Integrin alphaXbeta2 - immunology Integrin alphaXbeta2 - metabolism Macrophage-1 Antigen - genetics Macrophage-1 Antigen - immunology Macrophage-1 Antigen - metabolism Protease RNA Interference Sap2
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Beschreibung
Zusammenfassung:	Highlights • Complement factor H binds to human macrophages via CD11b/CD18 and CD11c/CD18. • Factor H enhances Candida albicans and zymosan induced release of IL-1β and IL-6. • Sap2 of Candida albicans inactivates factor H, CD11b/CD18 and CD11c/CD18.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.08.009