MICA078: A novel allele identified in a Moroccan individual affected by celiac disease

MICA078: A novel allele identified in a Moroccan individual affected by celiac disease

A novel MICA allele, MICA078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G arrow right A), resulting in one amino acid change at codon 142 (V arrow right I...

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Veröffentlicht in:Human immunology 2015-06, Vol.76 (6), p.438-441
Hauptverfasser: Piancatelli, Daniela, Oumhani, Khadija, Benelbarhdadi, Imane, Del Beato, Tiziana, Colanardi, Alessia, Sebastiani, Pierluigi, Tessitore, Alessandra, El Aouad, Rajae, Essaid, Abdellah
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Sprache:eng
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Zusammenfassung:A novel MICA allele, MICA078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G arrow right A), resulting in one amino acid change at codon 142 (V arrow right I) of MICA gene (compared to MICA002:01), located in the alpha 2-domain, in which V142 is the common residue.
ISSN:0198-8859
DOI:10.1016/j.humimm.2015.03.013