Protective effects of thrombomodulin on microvascular permeability after subarachnoid hemorrhage in mouse model

Highlights • There is a vasogenic brain edema after SAH as shown by MRI. • Apoptosis/inflammation in endothelium induced enhanced vascular permeability. • Thrombomodulin preserved vascular integrity via activated protein C/PAR-1 through blocking p38MAPK-p53/NF-κB pathway.

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Veröffentlicht in:	Neuroscience 2015-07, Vol.299, p.18-27
Hauptverfasser:	Xu, T, Zhang, W.-G, Sun, J, Zhang, Y, Lu, J.-F, Han, H.-B, Zhou, C.-M, Yan, J.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - drug effects Brain Edema - prevention & control Capillary Permeability - drug effects Disease Models, Animal Hippocampus - drug effects Male Mice Mice, Inbred ICR microvascular permeability Microvessels - drug effects mouse Neurology Neuroprotective Agents - administration & dosage subarachnoid hemorrhage Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - mortality thrombomodulin Thrombomodulin - administration & dosage
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Beschreibung
Zusammenfassung:	Highlights • There is a vasogenic brain edema after SAH as shown by MRI. • Apoptosis/inflammation in endothelium induced enhanced vascular permeability. • Thrombomodulin preserved vascular integrity via activated protein C/PAR-1 through blocking p38MAPK-p53/NF-κB pathway.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.04.058