Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy
Highlights • Intermittent ethanol-intoxicated rats exhibited a number of neurochemical changes. • GABA, tNAA, and GSH levels were significantly altered among different ethanol doses. • Six pairs of metabolite levels were significantly correlated with each other. • Our findings suggest several key ma...
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| Veröffentlicht in: | Neuroscience 2014-03, Vol.262, p.107-117 |
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| creator | Lee, Do-Wan Nam, Yoon-Ki Kim, Tai-Kyung Kim, Jae-Hwa Kim, Sang-Young Min, Jung-Whan Lee, Jung-Hoon Kim, Hwi-Yool Kim, Dai-Jin Choe, Bo-Young |
| description | Highlights • Intermittent ethanol-intoxicated rats exhibited a number of neurochemical changes. • GABA, tNAA, and GSH levels were significantly altered among different ethanol doses. • Six pairs of metabolite levels were significantly correlated with each other. • Our findings suggest several key markers in detecting binge alcohol-abusing patients. |
| doi_str_mv | 10.1016/j.neuroscience.2013.12.061 |
| format | Article |
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Psychology ; gamma-Aminobutyric Acid - metabolism ; Glutathione - pharmacology ; high-resolution spectra ; Inositol - metabolism ; intermittent ethanol intoxication ; Male ; metabolites ; Neurology ; Nuclear Magnetic Resonance, Biomolecular ; Rats ; Rats, Wistar ; Taurine - metabolism ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2014-03, Vol.262, p.107-117</ispartof><rights>IBRO</rights><rights>2014 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-42f3edd4f66fb99626da18d94e2897a42fd3cde9f735e1ca21ba268cb13540383</citedby><cites>FETCH-LOGICAL-c498t-42f3edd4f66fb99626da18d94e2897a42fd3cde9f735e1ca21ba268cb13540383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452213010944$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28318367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24406441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Do-Wan</creatorcontrib><creatorcontrib>Nam, Yoon-Ki</creatorcontrib><creatorcontrib>Kim, Tai-Kyung</creatorcontrib><creatorcontrib>Kim, Jae-Hwa</creatorcontrib><creatorcontrib>Kim, Sang-Young</creatorcontrib><creatorcontrib>Min, Jung-Whan</creatorcontrib><creatorcontrib>Lee, Jung-Hoon</creatorcontrib><creatorcontrib>Kim, Hwi-Yool</creatorcontrib><creatorcontrib>Kim, Dai-Jin</creatorcontrib><creatorcontrib>Choe, Bo-Young</creatorcontrib><title>Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • Intermittent ethanol-intoxicated rats exhibited a number of neurochemical changes. • GABA, tNAA, and GSH levels were significantly altered among different ethanol doses. • Six pairs of metabolite levels were significantly correlated with each other. • Our findings suggest several key markers in detecting binge alcohol-abusing patients.</description><subject>Alanine - metabolism</subject><subject>Alcoholic Intoxication - metabolism</subject><subject>Animals</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>brain</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol - pharmacology</subject><subject>frontal cortex</subject><subject>Frontal Lobe - drug effects</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Glutathione - pharmacology</subject><subject>high-resolution spectra</subject><subject>Inositol - metabolism</subject><subject>intermittent ethanol intoxication</subject><subject>Male</subject><subject>metabolites</subject><subject>Neurology</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Taurine - metabolism</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksuKFDEUhgtRnHH0FSQIgptqc6ubC0FmvMGAC3UdUsmp6bTVSZukmukH8_08sdsLbjQEAsn3_zk5f6rqCaMrRln7fLPysMSQjANvYMUpEyvGV7Rld6pz1nei7hop71bnVNC2lg3nZ9WDlDYURyPF_eqMS0lbKdl59e0qJKgt7MBb8Jk4P81LsSVhImkdYq4zxC3ul8XlXCDIa-3DXDbDrTM6u-AJTgMRxqhn8qM-s4YtHs7EIH0DCXESdU7EQgaTwZLxQOCW7N0-kF0MGR38YmbQkWz1jYfsDImQgtelnrRDUXl12B0eVvcmPSd4dFovqs9vXn-6fFdff3j7_vLVdW3k0Oda8kmAtXJq22kchpa3VrPeDhJ4P3Qaj60wFoapEw0wozkbNW97MzLRSCp6cVE9O_pieV8XSFltXTIwz9pDWJJiKBzY0HH2b7ShrBdC9sX1xRE1-JwUYVK76LY6HhSjqiSsNurPhFVJWDGuMGEUPz7ds4xbsL-kPyNF4OkJ0Am7P0Xsnku_uV5gHW2H3NWRA2zg3kFUp-usi9hpZYP7v3pe_mVjZudL7l_gAGkTlugxIsVUQoH6WP5k-ZJMUEYHKcV3rPbluA</recordid><startdate>20140314</startdate><enddate>20140314</enddate><creator>Lee, Do-Wan</creator><creator>Nam, Yoon-Ki</creator><creator>Kim, Tai-Kyung</creator><creator>Kim, Jae-Hwa</creator><creator>Kim, Sang-Young</creator><creator>Min, Jung-Whan</creator><creator>Lee, Jung-Hoon</creator><creator>Kim, Hwi-Yool</creator><creator>Kim, Dai-Jin</creator><creator>Choe, Bo-Young</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20140314</creationdate><title>Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy</title><author>Lee, Do-Wan ; Nam, Yoon-Ki ; Kim, Tai-Kyung ; Kim, Jae-Hwa ; Kim, Sang-Young ; Min, Jung-Whan ; Lee, Jung-Hoon ; Kim, Hwi-Yool ; Kim, Dai-Jin ; Choe, Bo-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-42f3edd4f66fb99626da18d94e2897a42fd3cde9f735e1ca21ba268cb13540383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alanine - metabolism</topic><topic>Alcoholic Intoxication - metabolism</topic><topic>Animals</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>brain</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - pharmacology</topic><topic>frontal cortex</topic><topic>Frontal Lobe - drug effects</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Glutathione - pharmacology</topic><topic>high-resolution spectra</topic><topic>Inositol - metabolism</topic><topic>intermittent ethanol intoxication</topic><topic>Male</topic><topic>metabolites</topic><topic>Neurology</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Taurine - metabolism</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Do-Wan</creatorcontrib><creatorcontrib>Nam, Yoon-Ki</creatorcontrib><creatorcontrib>Kim, Tai-Kyung</creatorcontrib><creatorcontrib>Kim, Jae-Hwa</creatorcontrib><creatorcontrib>Kim, Sang-Young</creatorcontrib><creatorcontrib>Min, Jung-Whan</creatorcontrib><creatorcontrib>Lee, Jung-Hoon</creatorcontrib><creatorcontrib>Kim, Hwi-Yool</creatorcontrib><creatorcontrib>Kim, Dai-Jin</creatorcontrib><creatorcontrib>Choe, Bo-Young</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Do-Wan</au><au>Nam, Yoon-Ki</au><au>Kim, Tai-Kyung</au><au>Kim, Jae-Hwa</au><au>Kim, Sang-Young</au><au>Min, Jung-Whan</au><au>Lee, Jung-Hoon</au><au>Kim, Hwi-Yool</au><au>Kim, Dai-Jin</au><au>Choe, Bo-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2014-03-14</date><risdate>2014</risdate><volume>262</volume><spage>107</spage><epage>117</epage><pages>107-117</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights • Intermittent ethanol-intoxicated rats exhibited a number of neurochemical changes. • GABA, tNAA, and GSH levels were significantly altered among different ethanol doses. • Six pairs of metabolite levels were significantly correlated with each other. • Our findings suggest several key markers in detecting binge alcohol-abusing patients.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>24406441</pmid><doi>10.1016/j.neuroscience.2013.12.061</doi><tpages>11</tpages></addata></record> |
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| subjects | Alanine - metabolism Alcoholic Intoxication - metabolism Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Body Weight brain Central Nervous System Depressants - pharmacology Dose-Response Relationship, Drug Ethanol - pharmacology frontal cortex Frontal Lobe - drug effects Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutathione - pharmacology high-resolution spectra Inositol - metabolism intermittent ethanol intoxication Male metabolites Neurology Nuclear Magnetic Resonance, Biomolecular Rats Rats, Wistar Taurine - metabolism Time Factors Vertebrates: nervous system and sense organs |
| title | Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy |
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