Dose-dependent influence of short-term intermittent ethanol intoxication on cerebral neurochemical changes in rats detected by ex vivo proton nuclear magnetic resonance spectroscopy

Highlights • Intermittent ethanol-intoxicated rats exhibited a number of neurochemical changes. • GABA, tNAA, and GSH levels were significantly altered among different ethanol doses. • Six pairs of metabolite levels were significantly correlated with each other. • Our findings suggest several key ma...

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Veröffentlicht in:	Neuroscience 2014-03, Vol.262, p.107-117
Hauptverfasser:	Lee, Do-Wan, Nam, Yoon-Ki, Kim, Tai-Kyung, Kim, Jae-Hwa, Kim, Sang-Young, Min, Jung-Whan, Lee, Jung-Hoon, Kim, Hwi-Yool, Kim, Dai-Jin, Choe, Bo-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism Alcoholic Intoxication - metabolism Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Body Weight brain Central Nervous System Depressants - pharmacology Dose-Response Relationship, Drug Ethanol - pharmacology frontal cortex Frontal Lobe - drug effects Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutathione - pharmacology high-resolution spectra Inositol - metabolism intermittent ethanol intoxication Male metabolites Neurology Nuclear Magnetic Resonance, Biomolecular Rats Rats, Wistar Taurine - metabolism Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Intermittent ethanol-intoxicated rats exhibited a number of neurochemical changes. • GABA, tNAA, and GSH levels were significantly altered among different ethanol doses. • Six pairs of metabolite levels were significantly correlated with each other. • Our findings suggest several key markers in detecting binge alcohol-abusing patients.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.12.061