Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

Highlights • Telmisartan enhances microglia M2 polarization in vitro , reducing LPS-induced inflammation. • Telmisartan activates AMPK in microglia cell cultures. • Telmisartan-induced M2 polarization and AMPK activation are CaMKKβ-dependent. • AMPK is required for the telmisartan reduction of LPS-i...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.298-313
Hauptverfasser:	Xu, Yuan, Xu, Yazhou, Wang, Yurong, Wang, Yunjie, He, Ling, Jiang, Zhenzhou, Huang, Zhangjian, Liao, Hong, Li, Jia, Saavedra, Juan M, Zhang, Luyong, Pang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Angiotensin II Type 1 Receptor Blockers - administration & dosage Animals Benzimidazoles - administration & dosage Benzoates - administration & dosage Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Cell Polarity - drug effects Cerebral Cortex - drug effects Cerebral Cortex - metabolism Encephalitis - chemically induced Encephalitis - metabolism HeLa Cells Humans Illness Behavior - drug effects Lipopolysaccharides - administration & dosage Mice Microglia - drug effects Microglia - metabolism Microglia - physiology Microglia polarization Neuroinflammation Psychiatry Signal Transduction - drug effects Telmisartan
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Zusammenfassung:	Highlights • Telmisartan enhances microglia M2 polarization in vitro , reducing LPS-induced inflammation. • Telmisartan activates AMPK in microglia cell cultures. • Telmisartan-induced M2 polarization and AMPK activation are CaMKKβ-dependent. • AMPK is required for the telmisartan reduction of LPS-induced sickness behavior. • PPARγ participates in telmisartan-induced M2 activation and M1 inhibition.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.07.015