Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

Highlights • The ATP level in CSF is related to the severity of RBI. • ATP enhances microglial activity and amplifies inflammatory response. • Blockade of ATP–P2X7R mediated signaling reduces RBI. • PI3K/AKT and NF-κB signal pathways are involved in RBI.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.87-100
Hauptverfasser:	Xu, Pengfei, Xu, Yongteng, Hu, Bin, Wang, Jue, Pan, Rui, Murugan, Madhuvika, Wu, Long-Jun, Tang, Yamei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - adverse effects Adenosine Triphosphate - cerebrospinal fluid Allergy and Immunology Animals BBG Brain - drug effects Brain - metabolism Brain - radiation effects Brain Injuries - cerebrospinal fluid Brain Injuries - etiology Brain Injuries - metabolism Cells, Cultured COX-2 Extracellular ATP Female Humans IL-6 Inflammation Inflammation - metabolism Male Mice Microglia Microglia - drug effects Microglia - metabolism Microglia - radiation effects P2X7R Paracrine Communication Psychiatry Radiation Injuries - cerebrospinal fluid Radiation Injuries - complications Radiation Injuries - metabolism Radiation-induced brain injury Radiotherapy - adverse effects Receptors, Purinergic P2X7 - metabolism Signal Transduction - drug effects Signal Transduction - radiation effects TNF-α
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Beschreibung
Zusammenfassung:	Highlights • The ATP level in CSF is related to the severity of RBI. • ATP enhances microglial activity and amplifies inflammatory response. • Blockade of ATP–P2X7R mediated signaling reduces RBI. • PI3K/AKT and NF-κB signal pathways are involved in RBI.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.06.020