Protective effect of the leaves of Vitex negundo against ethanol-induced cerebral oxidative stress in rats

The present study investigated the effect of the various fractions of hydromethanolic extract of the leaves of Vitex negundo (Verbenaceae) against ethanol-induced cerebral oxidative stress in rats. Cerebral oxidative stress was induced by the administration of 20% ethanol (5 ml/100 gbw) for a period...

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Veröffentlicht in:Tanzania health research bulletin 2012, Vol.14 (1), p.21-28
Hauptverfasser: Umamaheswari, Muthuswamy, Asokkumar, Kuppusamy, Umamageswari, Nandagopi, Sivashanmugam, Thirumalaisamy, Subhadradevi, Varadharajan
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Sprache:eng
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Zusammenfassung:The present study investigated the effect of the various fractions of hydromethanolic extract of the leaves of Vitex negundo (Verbenaceae) against ethanol-induced cerebral oxidative stress in rats. Cerebral oxidative stress was induced by the administration of 20% ethanol (5 ml/100 gbw) for a period of 28 days. The petroleum ether (PEF), chloroform (CF), ethylacetate (EAF) and residual (RF) fractions at a dose of 200 mg/kgbw orally were simultaneously administered with ethanol for 28 days. α-tocopherol at a dose of 100 mg/kg orally was used as the standard. Administration of ethanol resulted in a significant elevation in serum biochemical parameters like aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), uric acid, triglycerides and lipoprotein levels. In addition there was a significant (P
ISSN:1821-6404
0856-6496
0856-6496
DOI:10.4314/thrb.v14i1.5