What potential is there for the use of ZrO2 nanostructures for image-guided thermotherapy?

[...]the size of ZrO2 nanoparticles can be easily adjusted into a reasonable range, ideal passive targeting effect (EPR effect) can make the ZrO2 nanoparticles be transported to target tissue with carrying a large amount of payloads. [...]the surface of ZrO2 nanoparticles is fulfilled with functional groups, which can be easily combined with highly hydrophilic molecules such as poly(ethylene glycol) for prolonged in vivo circulation and with targeting ligands for enhancement of tumor targeting. [...]conjugation of ZrO2 nanocarriers with target-specific moieties will assume an increasingly important role to develop effective theranostic agents for performance optimization, for example, prolonged circulation time, RES avoidance, barrier penetration. Furthermore, there have been a number of great innovations in terms of integration of therapeutics with ZrO2 nanocarriers, for example, chemotherapy, antibody, gene therapy and hyperthermia-based cancer treatment besides microwave thermotherapy. [...]combination of different therapies, for example, chemotherapeutic/thermotherapeutic, chemotherapeutic/gene therapeutic, chemotherapeutic/photodynamic and photodynamic/thermotherapeutic, will lead to unprecedented synergistic therapeutic efficacy with ZrO2 nanocarriers.