Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2

The aims of this study were to investigate the immunohisto-chemical expression and potential prognostic significance of putative cancer stems cell markers ALDH1, EZH2 and SOX2 in prostate cancer. A total of 142 consecutive radical prostatectomies submitted to one laboratory with a diagnosis of prost...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology 2015-12, Vol.47 (7), p.622-628
Hauptverfasser:	Matsika, Admire, Srinivasan, Bhuvana, Day, Christopher, Mader, Sabrina Ann, Margaret Kiernan, Deirdre, Broomfield, Amy, Fu, Jinlin, Hooper, John D., Kench, James G., Samaratunga, Hemamali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged ALDH1 androgen receptor Biomarkers, Tumor - analysis cancer stem cell theory cancer stem cells Enhancer of Zeste Homolog 2 Protein EZH2 Humans Immunohistochemistry Isoenzymes - analysis Isoenzymes - biosynthesis Male Middle Aged Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Polycomb Repressive Complex 2 - analysis Polycomb Repressive Complex 2 - biosynthesis prognostic markers prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Retinal Dehydrogenase - analysis Retinal Dehydrogenase - biosynthesis SOX2 SOXB1 Transcription Factors - analysis SOXB1 Transcription Factors - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The aims of this study were to investigate the immunohisto-chemical expression and potential prognostic significance of putative cancer stems cell markers ALDH1, EZH2 and SOX2 in prostate cancer. A total of 142 consecutive radical prostatectomies submitted to one laboratory with a diagnosis of prostatic adenocarcinoma between 2008 and 2012 were retrieved and retrospectively studied. Immunohistochemistry for the three markers was performed in each case and both univariate and multivariate analyses were undertaken to evaluate the correlation between the staining patterns and known histopathological prognostic features. ALDH1 showed a statistically significant association with tumour stage p
ISSN:	0031-3025 1465-3931
DOI:	10.1097/PAT.0000000000000325