Metal-Free Approach for the Synthesis of N‑Aryl Sulfoximines via Aryne Intermediate

Metal-Free Approach for the Synthesis of N‑Aryl Sulfoximines via Aryne Intermediate

A metal-free and operationally simple N-arylation of NH-sulfoximines with aryne precursors is reported. Transition metal-free reaction conditions and shorter reaction times are the highlights of the present method. The mild optimized condition was also found to be suitable with enantiopure substrate...

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Veröffentlicht in:Organic letters 2015-11, Vol.17 (22), p.5547-5549
Hauptverfasser: Aithagani, Sravan Kumar, Dara, Saidulu, Munagala, Gurunadham, Aruri, Hariprasad, Yadav, Mahipal, Sharma, Shweta, Vishwakarma, Ram A, Singh, Parvinder Pal
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Sprache:eng
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Zusammenfassung:A metal-free and operationally simple N-arylation of NH-sulfoximines with aryne precursors is reported. Transition metal-free reaction conditions and shorter reaction times are the highlights of the present method. The mild optimized condition was also found to be suitable with enantiopure substrates.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02804