Adverse cognitive effects of antiepileptic pharmacotherapy: Each additional drug matters

Abstract The study was set up to evaluate the impact of the total drug load of antiepileptic pharmacotherapy on cognition. Retrospective analyses were based on 834 patients with epilepsy who underwent a brief routine assessment of executive function and verbal memory (EpiTrack Plus) at our departmen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European neuropsychopharmacology 2015-11, Vol.25 (11), p.1954-1959
Hauptverfasser:	Witt, Juri-Alexander, Elger, Christian E, Helmstaedter, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Antiepileptic drugs Cognition Cognition - drug effects Drug Therapy, Combination - adverse effects Epilepsy Epilepsy - drug therapy Epilepsy - epidemiology Epilepsy - psychology Executive Function - drug effects Female Humans Internal Medicine Male Memory - drug effects Neuropsychology Psychiatry Psychological Tests Retrospective Studies Seizures - drug therapy Seizures - epidemiology Seizures - psychology Side effects Tertiary Care Centers
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract The study was set up to evaluate the impact of the total drug load of antiepileptic pharmacotherapy on cognition. Retrospective analyses were based on 834 patients with epilepsy who underwent a brief routine assessment of executive function and verbal memory (EpiTrack Plus) at our department. The total drug load was quantified in two ways: (1) number of concurrent antiepileptic drugs (AEDs) and (2) total drug load according to the defined daily dose (DDD) provided by the World Health Organization. The cognitive measures showed higher inverse correlations with the number of AEDs (executive function: r =−0.35, p
ISSN:	0924-977X 1873-7862
DOI:	10.1016/j.euroneuro.2015.07.027