Nano-porous nitrocellulose liquid bandage modulates cell and cytokine response and accelerates cutaneous wound healing in a mouse model

•A novel nano-porous nitrocellulose liquid bandage was prepared.•The L-Bandage supplied a suitable moist microenvironment for wound healing.•The effects of L-Bandage on full-thickness wounds in mice were investigated. Nitrocellulose liquid bandage (L-Bandage) is extensively used in hard-to-cover cut...

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Veröffentlicht in:Carbohydrate polymers 2016-01, Vol.136, p.618-629
Hauptverfasser: Mu, Xiaofeng, Yu, Hao, Zhang, Caizhen, Chen, Xiufang, Cheng, Zhiyun, Bai, Ruyu, Wu, Xunxun, Yu, Qian, Wu, Chunlin, Diao, Yong
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Sprache:eng
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Zusammenfassung:•A novel nano-porous nitrocellulose liquid bandage was prepared.•The L-Bandage supplied a suitable moist microenvironment for wound healing.•The effects of L-Bandage on full-thickness wounds in mice were investigated. Nitrocellulose liquid bandage (L-Bandage) is extensively used in hard-to-cover cuts and wounds management, owing to its flexibility, softness, transparency, and conformability. However, evidence supporting their mechanisms of action as wound dressing is scanty. This study introduces a novel nano-porous L-Bandage, and provides results from a mouse full-thickness wound model investigating its mechanism of action on wound healing. Different characteristics, such as porosity, mechanical properties and water vapor transmission rate (WVTR) were determined. The L-Bandage formed film had a porous network structure with mean diameter of 18nm that could effectively prevent the bacterial invasion, and favorable properties of tensile strength, elongation, and WVTR. The L-Bandage treated wound exhibited accelerated healing, with reduced inflammations, enhanced wound re-epithelialization, contraction, granulation tissue formation, and rapid angiogenesis. Our data suggested that L-Bandage could serve as a promising wound dressing, because of its desirable properties for wound healing.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2015.08.070