The Hruska postulate of Crohn’s disease

Abstract Crohn’s disease is due to the loss of immunological tolerance within the gastrointestinal tract to the antigenic array of Mycobacterium avium subspecies paratuberculosis (MAP) and closely related polymorphic variants. The loss of immune tolerance results in an effector cytokine responsive u...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Medical hypotheses 2015-12, Vol.85 (6), p.878-881
1. Verfasser:	Monif, Gilles R.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Autoimmunity Breast Feeding Colitis - microbiology Crohn Disease - diagnosis Crohn Disease - microbiology Crohn Disease - physiopathology Cytokines - metabolism Dairying Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Humans Immune System Immune Tolerance Internal Medicine Milk - microbiology Mycobacterium avium subsp. paratuberculosis Protein Binding
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Crohn’s disease is due to the loss of immunological tolerance within the gastrointestinal tract to the antigenic array of Mycobacterium avium subspecies paratuberculosis (MAP) and closely related polymorphic variants. The loss of immune tolerance results in an effector cytokine responsive upon re-exposure to MAP. For immune tolerance to MAP to be induced, infection must occur when acquired immunity is markedly underdeveloped.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/j.mehy.2015.09.019