Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets

Highlights • A TK/gE/gI triple gene-deleted Pseudorabies virus derived from current circulating field isolate HN1201 strain was generated by using bacterial artificial chromosome techniques. • Rescued virus showed reduced plaque size to its parent strain. • Efficacy study has been performed on 9 day...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-05, Vol.33 (21), p.2432-2437
Hauptverfasser:	Zhang, Chaolin, Guo, Linghua, Jia, Xiangrui, Wang, Tongyan, Wang, Juan, Sun, Zhe, Wang, Lilin, Li, Xiangdong, Tan, Feifei, Tian, Kegong
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Viral - blood China Gene Deletion Genes Herpesvirus 1, Suid - genetics Herpesvirus 1, Suid - immunology Hogs Mortality Pseudorabies - prevention & control Pseudorabies Vaccines - administration & dosage Pseudorabies Vaccines - genetics Pseudorabies Vaccines - immunology Pseudorabies Vaccines - isolation & purification Pseudorabies virus Survival Analysis Swine Swine Diseases - prevention & control TK/gE/gI deletion Vaccine Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vaccines, Attenuated - isolation & purification Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - isolation & purification Virus variant
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • A TK/gE/gI triple gene-deleted Pseudorabies virus derived from current circulating field isolate HN1201 strain was generated by using bacterial artificial chromosome techniques. • Rescued virus showed reduced plaque size to its parent strain. • Efficacy study has been performed on 9 day-old piglets and results showed that vaccination can provide full protection to the virulent PRV HN1201 challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.03.094