Lactate Dehydrogenase Activity in the Cerebral Cortex and Hippocampus of Mongolian Gerbils in Ischemic and Reperfusion Injuries

The aim of the present work was to analyze changes in lactate dehydrogenase (LDH) activity in the cytoplasm of neurons in the hippocampus and cerebral cortex on Mongolian gerbils ( Meriones unguiculatus ) in the early and late reperfusion periods after global ischemia. LDH activity in pyramidal neur...

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Veröffentlicht in:Neuroscience and behavioral physiology 2013-10, Vol.43 (8), p.941-945
Hauptverfasser: Shcherbak, N. S., Galagudza, M. M., Ovchinnikov, D. A., Kuz’menkov, A. N., Yukina, G. Yu, Barantsevich, E. R., Tomson, V. V., Shlyakhto, E. V.
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container_end_page 945
container_issue 8
container_start_page 941
container_title Neuroscience and behavioral physiology
container_volume 43
creator Shcherbak, N. S.
Galagudza, M. M.
Ovchinnikov, D. A.
Kuz’menkov, A. N.
Yukina, G. Yu
Barantsevich, E. R.
Tomson, V. V.
Shlyakhto, E. V.
description The aim of the present work was to analyze changes in lactate dehydrogenase (LDH) activity in the cytoplasm of neurons in the hippocampus and cerebral cortex on Mongolian gerbils ( Meriones unguiculatus ) in the early and late reperfusion periods after global ischemia. LDH activity in pyramidal neurons in various hippocampal fields and in neurons in cerebral cortex layers II, III, and V after 7-min forebrain ischemia was found to depend on the locations of these neuron types and the duration of postischemic reperfusion. The dynamics of LDH activity in neurons were characterized by a significant decrease two days after reperfusion, with different levels of normalization by day 7 of the reperfusion period.
doi_str_mv 10.1007/s11055-013-9832-y
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source SpringerNature Journals
subjects Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain damage
Carotid arteries
Cytoplasm
Dehydrogenases
Endocrinology
Enzymes
Ischemia
Laboratory animals
Meriones unguiculatus
Metabolism
Neurobiology
Neurons
Neurosciences
Veins & arteries
title Lactate Dehydrogenase Activity in the Cerebral Cortex and Hippocampus of Mongolian Gerbils in Ischemic and Reperfusion Injuries
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