Lactate Dehydrogenase Activity in the Cerebral Cortex and Hippocampus of Mongolian Gerbils in Ischemic and Reperfusion Injuries

The aim of the present work was to analyze changes in lactate dehydrogenase (LDH) activity in the cytoplasm of neurons in the hippocampus and cerebral cortex on Mongolian gerbils ( Meriones unguiculatus ) in the early and late reperfusion periods after global ischemia. LDH activity in pyramidal neurons in various hippocampal fields and in neurons in cerebral cortex layers II, III, and V after 7-min forebrain ischemia was found to depend on the locations of these neuron types and the duration of postischemic reperfusion. The dynamics of LDH activity in neurons were characterized by a significant decrease two days after reperfusion, with different levels of normalization by day 7 of the reperfusion period.