Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in rats

Highlights • Repetitive colorectal distention induced visceral hypersensitivity and ACC sensitization. • Theta band power in the ACC was modulated by repetitive colorectal distention. • Visceral stimulation facilitates ACC neural firing phase-locked with theta oscillations. • Thalamo-ACC theta oscil...

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Veröffentlicht in:	Neuroscience 2015-07, Vol.298, p.200-210
Hauptverfasser:	Wang, J, Cao, B, Yu, T.R, Jelfs, B, Yan, J, Chan, R.H.M, Li, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals anterior cingulate cortex Biological Clocks - physiology Colon - innervation Disease Models, Animal Electric Stimulation Gyrus Cinguli - pathology Male Neurology Neurons - physiology Patch-Clamp Techniques phase-locking Principal Component Analysis Rats Rats, Sprague-Dawley thalamocortical synchronization Thalamus - physiopathology theta oscillation Theta Rhythm - physiology Time Factors visceral pain Visceral Pain - pathology
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Zusammenfassung:	Highlights • Repetitive colorectal distention induced visceral hypersensitivity and ACC sensitization. • Theta band power in the ACC was modulated by repetitive colorectal distention. • Visceral stimulation facilitates ACC neural firing phase-locked with theta oscillations. • Thalamo-ACC theta oscillations synchronized after repetitive CRD.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.04.024