Prognosis of Progressive Cognitive Deficit in Elderly Patients with Mild Cognitive Impairment Receiving Long-Term Treatment (3-year observations)

The aim of the present work was to assess individual prognoses for Cerebrolysin treatment efficacy in mild cognitive impairment syndrome (MCIS) and to identify the most informative tests for prognosticating the development of dementia. A total of 53 patients with the amnestic type of MCIS were treated with Cerebrolysin for three years with regular neuropsychological and psychiatric clinical testing, with analysis of the results by nonparametric statistics, cluster analysis, and linear discriminant analysis. This combination of mathematical methods allowed decreases in cognitive functions to the level of dementia to be predicted. A “risk group” with a rapid decrease in cognitive functions and the threat of dementia was identified,i.e., a group with low therapeutic efficacy. Tests were ranked in terms of their prognostic value.