Inactivated West Nile Virus (WNV) vaccine, Duvaxyn WNV, protects against a highly neuroinvasive lineage 2 WNV strain in mice

Highlights • Lineage 2 WNV causes encephalitis in humans and horses in South Africa and Europe. • Commercial vaccines’ efficacy is evaluated against WNV lineage 1 strains only. • Duvaxyn WNV vaccine protected completely against challenge with lineage 2 in mice. • Significant cross neutralising antib...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (37), p.3856-3862
Hauptverfasser:	Venter, Marietjie, van Vuren, Petrus Janse, Mentoor, Juliet, Paweska, Janusz, Williams, June
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies Antibodies, Neutralizing - blood Applied microbiology Biological and medical sciences blood serum Brain - immunology Brain - virology Cross protection Cross Reactions Duvaxyn WNV vaccine encephalitis Fatalities Fundamental and applied biological sciences. Psychology Horses Horses - immunology humans Immunization immunohistochemistry Inactivated vaccine Lineage 1 Lineage 2 Male Mice Mice, Inbred BALB C Microbiology Miscellaneous Mortality Neutralising antibodies neutralization neutralizing antibodies reverse transcriptase polymerase chain reaction RNA, Viral - analysis Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Inactivated - immunology Vaccines, Inactivated - pharmacology Vector-borne diseases Virology viruses West Nile Fever - epidemiology West Nile Fever - mortality West Nile Fever - prevention & control West Nile Virus West Nile virus - pathogenicity West Nile Virus Vaccines - immunology West Nile Virus Vaccines - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • Lineage 2 WNV causes encephalitis in humans and horses in South Africa and Europe. • Commercial vaccines’ efficacy is evaluated against WNV lineage 1 strains only. • Duvaxyn WNV vaccine protected completely against challenge with lineage 2 in mice. • Significant cross neutralising antibodies was detected in vaccinated mice. • This vaccine could protect against lineage 2 WNV neurological disease in horses.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.06.059