Use of a GnRH vaccine, GonaCon™, for prevention and treatment of adrenocortical disease (ACD) in domestic ferrets

Highlights • A vaccine to prevent adrenal cortical disease (ACD) in domestic ferrets is proposed. • GonaCon immunocontraceptive vaccine prevented ACD by causing production of antibodies to GnRH. • ACD was reduced in ferrets treated with GonaCon compared to untreated ferrets. • Subcutaneous vaccinati...

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Veröffentlicht in:	Vaccine 2013-09, Vol.31 (41), p.4619-4623
Hauptverfasser:	Miller, Lowell A, Fagerstone, Kathleen A, Wagner, Robert A, Finkler, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	17 alpha -Hydroxyprogesterone 17-hydroxyprogesterone 17β-Estradiol adenocarcinoma Adrenal cortex Adrenal glands Adrenal hormones Adrenocortical Adenoma - prevention & control Adrenocortical Adenoma - veterinary Adrenocortical Carcinoma - prevention & control Adrenocortical Carcinoma - veterinary Adrenocortical disease (ACD) Adrenocortical Hyperfunction - prevention & control adverse effects aggression Allergy and Immunology Alopecia Androstenedione Animals Antibodies Applied microbiology Atrophy Biological and medical sciences Domestic animals Domestic ferret Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology estradiol Female females Ferrets Fertility Fundamental and applied biological sciences. Psychology GonaCon Gonadotropin-releasing hormone Gonadotropin-releasing hormone (GnRH) Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - immunology Health services Hormones Hyperplasia Immunization Immunologic contraceptives Injection injection site Injections, Intramuscular Injections, Subcutaneous intramuscular injection Luteinizing hormone luteinizing hormone receptors males Medical treatment Microbiology middle-aged adults muscular atrophy Mustela Mustela putorius furo probability Prostatitis Pruritus Rodents secretion Sex hormones Side effects Sterilization, Reproductive - adverse effects Steroid hormones Treatment Outcome vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Contraceptive - administration & dosage Vaccines, Contraceptive - adverse effects vulva Wildlife
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Beschreibung
Zusammenfassung:	Highlights • A vaccine to prevent adrenal cortical disease (ACD) in domestic ferrets is proposed. • GonaCon immunocontraceptive vaccine prevented ACD by causing production of antibodies to GnRH. • ACD was reduced in ferrets treated with GonaCon compared to untreated ferrets. • Subcutaneous vaccination with GonaCon is recommended to prevent onset of ACD in domestic ferrets.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.07.035