Influenza vaccine: Development of a novel intranasal and subcutaneous recombinant adjuvant

Highlights • GK-1 was recombinantly expressed fused to the pVIII surface protein of the paghemid M13 (FGK1). • Intranasal and parenteral co-immunization of FGK1 with the influenza vaccine increase specific levels of antibodies in mice. • Parenteral co-immunization of FGK1 with the influenza vaccine...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (37), p.4009-4016
Hauptverfasser:	Segura-Velázquez, R, Cervantes, J, Acosta, E, Sánchez-Betancourt, I, Villalobos, N, Rodarte, L.F, Restelli, M, Fragoso, G, Sciutto, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic - genetics Adjuvants, Immunologic - pharmacology Administration, Intranasal Allergy and Immunology Animals antibodies Antibodies, Viral - blood Applied microbiology Bacteriophage M13 - genetics Biological and medical sciences blood serum Bronchoalveolar Lavage Fluid - immunology Female Fundamental and applied biological sciences. Psychology Hogs human influenza Immunization immunoglobulin A Immunoglobulin A - blood immunoglobulin G Immunoglobulin G - blood Influenza Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza Vaccines - pharmacology Infusions, Parenteral Injections, Subcutaneous Intranasal immunization Maternal Age Mice Mice, Inbred BALB C Microbiology Miscellaneous Peptides Peptides - immunology Phages Polysorbates - administration & dosage Polysorbates - pharmacology Squalene - administration & dosage Squalene - pharmacology Swine synthetic peptides Taenia Taenia crassiceps Vaccination Vaccination - methods Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology
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Beschreibung
Zusammenfassung:	Highlights • GK-1 was recombinantly expressed fused to the pVIII surface protein of the paghemid M13 (FGK1). • Intranasal and parenteral co-immunization of FGK1 with the influenza vaccine increase specific levels of antibodies in mice. • Parenteral co-immunization of FGK1 with the influenza vaccine increases levels of specific IgG in pigs. • A new low costly adjuvant, adequate for veterinary purposes is developed.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.05.044