Changes in Streptococcus pneumoniae serotype distribution in invasive disease and nasopharyngeal carriage after the heptavalent pneumococcal conjugate vaccine introduction in Bogotá, Colombia

Highlights • Pneumococcal nasopharyngeal carriage prevalence declined in vaccinated children. • The PCV7-serotypes rate was lower in vaccinated than unvaccinated children. • In invasive pneumococcal disease, PCV7 serotypes changed in pre and post-vaccine period. • The results provide a baseline to d...

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Veröffentlicht in:	Vaccine 2013-08, Vol.31 (37), p.4033-4038
Hauptverfasser:	Parra, Eliana L, De La Hoz, Fernando, Díaz, Paula L, Sanabria, Olga, Realpe, María Elena, Moreno, Jaime
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Anti-Bacterial Agents - pharmacology Applied microbiology Bacteriology Biological and medical sciences Carrier State - immunology ceftriaxone childhood children chloramphenicol Colombia Cross-Sectional Studies Deoxyribonucleic acid Disease DNA erythromycin Female Fundamental and applied biological sciences. Psychology Heptavalent Pneumococcal Conjugate Vaccine Humans Immunization Infant Laboratories Male meningitis Microbial Sensitivity Tests Microbiology Miscellaneous monitoring Mortality Nasopharyngeal carriage Nasopharynx - drug effects Nasopharynx - microbiology Pneumococcal conjugate vaccine Pneumococcal Infections - prevention & control Pneumococcal Vaccines - therapeutic use Pneumonia polymerase chain reaction serotypes Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics Streptococcus pneumoniae - immunology Streptococcus pneumoniae - isolation & purification Streptococcus pneumoniae serotypes Surveillance surveys tetracycline Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • Pneumococcal nasopharyngeal carriage prevalence declined in vaccinated children. • The PCV7-serotypes rate was lower in vaccinated than unvaccinated children. • In invasive pneumococcal disease, PCV7 serotypes changed in pre and post-vaccine period. • The results provide a baseline to determine the vaccine impact in Bogotá.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.04.074