Serum levels of bone resorption markers are decreased in patients with type 2 diabetes
Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were mea...
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| Veröffentlicht in: | Acta diabetologica 2013-02, Vol.50 (1), p.47-52 |
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| creator | Reyes-García, Rebeca Rozas-Moreno, Pedro López-Gallardo, Gema García-Martín, Antonia Varsavsky, Mariela Avilés-Perez, Maria Dolores Muñoz-Torres, Manuel |
| description | Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml,
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| doi_str_mv | 10.1007/s00592-011-0347-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1732836590</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1732836590</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-87a5ae8a7aca8c6c14f0845cf857b37635e7fe41fc233d125f10e281084d370e3</originalsourceid><addsrcrecordid>eNqFkcFO3DAQhi3Uil0oD8ClstRLL4Hx2F47R7SigLQSB9peLa8zodlmk9ROQLx9vVqKUCXEaQ7zzT-a-Rg7FXAmAMx5AtAlFiBEAVKZAg7YXCiJhUYpP7A5lAoKrbCcsaOUNgACjbSHbIYICgWWc_bzjuK05S09UJt4X_N13xGPlPo4jE3f8a2Pvykm7iPxikIkn6jiTccHPzbUjYk_NuMvPj4NxJFXjV_TSOkT-1j7NtHJcz1mP75dfl9eF6vbq5vlxaoICvRYWOO1J-uND96GRRCqBqt0qK02a2kWUpOpSYk65IMqgboWQGhFhippgOQx-7rPHWL_Z6I0um2TArWt76ifkhNGopULXcL7KFrUQpoSM_rlP3TTT7HLh2TKWClBq12g2FMh9ilFqt0Qm_yuJyfA7fy4vR-X_bidH7eb-fycPK23VL1M_BOSAdwDKbe6e4qvVr-Z-hceYpjh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1278330540</pqid></control><display><type>article</type><title>Serum levels of bone resorption markers are decreased in patients with type 2 diabetes</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Reyes-García, Rebeca ; Rozas-Moreno, Pedro ; López-Gallardo, Gema ; García-Martín, Antonia ; Varsavsky, Mariela ; Avilés-Perez, Maria Dolores ; Muñoz-Torres, Manuel</creator><creatorcontrib>Reyes-García, Rebeca ; Rozas-Moreno, Pedro ; López-Gallardo, Gema ; García-Martín, Antonia ; Varsavsky, Mariela ; Avilés-Perez, Maria Dolores ; Muñoz-Torres, Manuel</creatorcontrib><description>Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml,
P
< 0.05. TRAP5b and CTX were positively correlated with i-PTH (CTX:
r
= 0.443,
P
< 0.001; TRAP5b:
r
= 0.180,
P
= 0.047). There was an inverse relationship between TRAP5b levels and diabetes duration (
r
= −0.269,
P
= 0.021). T2DM patients have lower levels of bone resorption markers, and i-PTH compared with subjects without diabetes. Lower levels of PTH may induce a low turnover state as reflected by lower levels of bone resorption markers, and this situation may influence the higher risk of fracture of T2DM.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-011-0347-0</identifier><identifier>PMID: 22042129</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Biomarkers ; Biomarkers - blood ; Bone Density ; Bone Resorption ; Correlation analysis ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - physiopathology ; Female ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Parathyroid Hormone - blood</subject><ispartof>Acta diabetologica, 2013-02, Vol.50 (1), p.47-52</ispartof><rights>Springer-Verlag 2011</rights><rights>Springer-Verlag Italia 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-87a5ae8a7aca8c6c14f0845cf857b37635e7fe41fc233d125f10e281084d370e3</citedby><cites>FETCH-LOGICAL-c405t-87a5ae8a7aca8c6c14f0845cf857b37635e7fe41fc233d125f10e281084d370e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-011-0347-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-011-0347-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22042129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reyes-García, Rebeca</creatorcontrib><creatorcontrib>Rozas-Moreno, Pedro</creatorcontrib><creatorcontrib>López-Gallardo, Gema</creatorcontrib><creatorcontrib>García-Martín, Antonia</creatorcontrib><creatorcontrib>Varsavsky, Mariela</creatorcontrib><creatorcontrib>Avilés-Perez, Maria Dolores</creatorcontrib><creatorcontrib>Muñoz-Torres, Manuel</creatorcontrib><title>Serum levels of bone resorption markers are decreased in patients with type 2 diabetes</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml,
P
< 0.05. TRAP5b and CTX were positively correlated with i-PTH (CTX:
r
= 0.443,
P
< 0.001; TRAP5b:
r
= 0.180,
P
= 0.047). There was an inverse relationship between TRAP5b levels and diabetes duration (
r
= −0.269,
P
= 0.021). T2DM patients have lower levels of bone resorption markers, and i-PTH compared with subjects without diabetes. Lower levels of PTH may induce a low turnover state as reflected by lower levels of bone resorption markers, and this situation may influence the higher risk of fracture of T2DM.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bone Density</subject><subject>Bone Resorption</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Parathyroid Hormone - blood</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkcFO3DAQhi3Uil0oD8ClstRLL4Hx2F47R7SigLQSB9peLa8zodlmk9ROQLx9vVqKUCXEaQ7zzT-a-Rg7FXAmAMx5AtAlFiBEAVKZAg7YXCiJhUYpP7A5lAoKrbCcsaOUNgACjbSHbIYICgWWc_bzjuK05S09UJt4X_N13xGPlPo4jE3f8a2Pvykm7iPxikIkn6jiTccHPzbUjYk_NuMvPj4NxJFXjV_TSOkT-1j7NtHJcz1mP75dfl9eF6vbq5vlxaoICvRYWOO1J-uND96GRRCqBqt0qK02a2kWUpOpSYk65IMqgboWQGhFhippgOQx-7rPHWL_Z6I0um2TArWt76ifkhNGopULXcL7KFrUQpoSM_rlP3TTT7HLh2TKWClBq12g2FMh9ilFqt0Qm_yuJyfA7fy4vR-X_bidH7eb-fycPK23VL1M_BOSAdwDKbe6e4qvVr-Z-hceYpjh</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Reyes-García, Rebeca</creator><creator>Rozas-Moreno, Pedro</creator><creator>López-Gallardo, Gema</creator><creator>García-Martín, Antonia</creator><creator>Varsavsky, Mariela</creator><creator>Avilés-Perez, Maria Dolores</creator><creator>Muñoz-Torres, Manuel</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20130201</creationdate><title>Serum levels of bone resorption markers are decreased in patients with type 2 diabetes</title><author>Reyes-García, Rebeca ; 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Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml,
P
< 0.05. TRAP5b and CTX were positively correlated with i-PTH (CTX:
r
= 0.443,
P
< 0.001; TRAP5b:
r
= 0.180,
P
= 0.047). There was an inverse relationship between TRAP5b levels and diabetes duration (
r
= −0.269,
P
= 0.021). T2DM patients have lower levels of bone resorption markers, and i-PTH compared with subjects without diabetes. Lower levels of PTH may induce a low turnover state as reflected by lower levels of bone resorption markers, and this situation may influence the higher risk of fracture of T2DM.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>22042129</pmid><doi>10.1007/s00592-011-0347-0</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biomarkers Biomarkers - blood Bone Density Bone Resorption Correlation analysis Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Female Humans Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Parathyroid Hormone - blood |
| title | Serum levels of bone resorption markers are decreased in patients with type 2 diabetes |
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