Serum levels of bone resorption markers are decreased in patients with type 2 diabetes

Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were mea...

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Veröffentlicht in:	Acta diabetologica 2013-02, Vol.50 (1), p.47-52
Hauptverfasser:	Reyes-García, Rebeca, Rozas-Moreno, Pedro, López-Gallardo, Gema, García-Martín, Antonia, Varsavsky, Mariela, Avilés-Perez, Maria Dolores, Muñoz-Torres, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers Biomarkers - blood Bone Density Bone Resorption Correlation analysis Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Female Humans Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Parathyroid Hormone - blood
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Zusammenfassung:	Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml, P
ISSN:	0940-5429 1432-5233
DOI:	10.1007/s00592-011-0347-0