ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs
Highlights • Fndc5 , PGC1α and BDNF act downstream of ERK1/2 signaling pathway. • CREB and PGC1α expression coordinate with Fndc5 expression upon ERK1/2 regulation. • Data indicated ERK1/2 MAPKs up-regulates Fndc5 expression via RA induction.
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| Veröffentlicht in: | Neuroscience 2015-06, Vol.297, p.252-261 |
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| container_title | Neuroscience |
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| creator | Hosseini Farahabadi, S.S Ghaedi, K Ghazvini Zadegan, F Karbalaie, K Rabiee, F Nematollahi, M Baharvand, H Nasr-Esfahani, M.-H |
| description | Highlights • Fndc5 , PGC1α and BDNF act downstream of ERK1/2 signaling pathway. • CREB and PGC1α expression coordinate with Fndc5 expression upon ERK1/2 regulation. • Data indicated ERK1/2 MAPKs up-regulates Fndc5 expression via RA induction. |
| doi_str_mv | 10.1016/j.neuroscience.2015.03.069 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antineoplastic Agents - pharmacology Benzamides - pharmacology bFGF Cell Differentiation - drug effects Cell Differentiation - physiology Computational Biology Diphenylamine - analogs & derivatives Diphenylamine - pharmacology Embryonic Stem Cells - drug effects Embryonic Stem Cells - physiology ERK1/2 Fibroblast Growth Factors - pharmacology Fibronectins - genetics Fibronectins - metabolism Fndc5 Gene Expression Regulation - physiology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 3 - metabolism neural differentiation Neurology PPAR alpha - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects signaling pathway Time Factors Tretinoin - pharmacology |
| title | ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs |
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