ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs

Highlights • Fndc5 , PGC1α and BDNF act downstream of ERK1/2 signaling pathway. • CREB and PGC1α expression coordinate with Fndc5 expression upon ERK1/2 regulation. • Data indicated ERK1/2 MAPKs up-regulates Fndc5 expression via RA induction.

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Veröffentlicht in:	Neuroscience 2015-06, Vol.297, p.252-261
Hauptverfasser:	Hosseini Farahabadi, S.S, Ghaedi, K, Ghazvini Zadegan, F, Karbalaie, K, Rabiee, F, Nematollahi, M, Baharvand, H, Nasr-Esfahani, M.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Benzamides - pharmacology bFGF Cell Differentiation - drug effects Cell Differentiation - physiology Computational Biology Diphenylamine - analogs & derivatives Diphenylamine - pharmacology Embryonic Stem Cells - drug effects Embryonic Stem Cells - physiology ERK1/2 Fibroblast Growth Factors - pharmacology Fibronectins - genetics Fibronectins - metabolism Fndc5 Gene Expression Regulation - physiology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 3 - metabolism neural differentiation Neurology PPAR alpha - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects signaling pathway Time Factors Tretinoin - pharmacology
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Zusammenfassung:	Highlights • Fndc5 , PGC1α and BDNF act downstream of ERK1/2 signaling pathway. • CREB and PGC1α expression coordinate with Fndc5 expression upon ERK1/2 regulation. • Data indicated ERK1/2 MAPKs up-regulates Fndc5 expression via RA induction.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.03.069