Metaplastic up-regulation of LTP in the rat visual cortex by monocular visual training: Requirement of task mastery, hemispheric specificity, and NMDA–GluN2B involvement

Highlights • Rats were trained in a visual discrimination task with one eye occluded. • Training enhanced LTP between the lateral geniculate nucleus and V1 in vivo. • This effect was seen only in the hemisphere contralateral to the open eye. • This effect was dependent on NMDA receptor–GluN2B subuni...

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Veröffentlicht in:	Neuroscience 2015-05, Vol.293, p.171-186
Hauptverfasser:	Hager, A.M, Gagolewicz, P.J, Rodier, S, Kuo, M.-C, Dumont, É.C, Dringenberg, H.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Discrimination (Psychology) - physiology Electric Stimulation Functional Laterality - physiology Geniculate Bodies - drug effects Geniculate Bodies - physiology GluN2B subunits long-term potentiation Long-Term Potentiation - drug effects Male Maze Learning - physiology metaplasticity Neurology NMDA receptor Phenols - administration & dosage Piperidines - administration & dosage Pyramidal Cells - drug effects Pyramidal Cells - physiology Rats Rats, Long-Evans Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors visual cortex Visual Cortex - drug effects Visual Cortex - physiology visual learning Visual Perception - physiology
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Zusammenfassung:	Highlights • Rats were trained in a visual discrimination task with one eye occluded. • Training enhanced LTP between the lateral geniculate nucleus and V1 in vivo. • This effect was seen only in the hemisphere contralateral to the open eye. • This effect was dependent on NMDA receptor–GluN2B subunits. • NMDA currents in V1 neurons in vitro were more sensitive to GluN2B antagonism.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.02.027