Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice

Highlights • BPA treatment increased fasted blood glucose level and plasma insulin level, even leaded to insulin resistance in adult mice. • BPA treatment decreased the insulin signaling, AKT, GSK3β and ERK phosphorylation in CNS. • BPA treatment impaired glucose uptake by decreasing GLUTs expressio...

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Veröffentlicht in:	General and comparative endocrinology 2015-02, Vol.212, p.44-50
Hauptverfasser:	Fang, Fangfang, Chen, Donglong, Yu, Pan, Qian, Wenyi, Zhou, Jing, Liu, Jingli, Gao, Rong, Wang, Jun, Xiao, Hang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzhydryl Compounds - pharmacology Bisphenol A Blotting, Western Brain - drug effects Brain - metabolism Brain insulin resistance Endocrinology & Metabolism Free Radical Scavengers - pharmacology Glucose - metabolism Glucose Tolerance Test Glucose Transport Proteins, Facilitative - metabolism Glucose transporter Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Homeostasis - drug effects Insulin - metabolism Insulin Receptor Substrate Proteins - metabolism Insulin Resistance Male Mice Mice, Inbred C57BL Phenols - pharmacology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Insulin - metabolism Signal Transduction - drug effects
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Zusammenfassung:	Highlights • BPA treatment increased fasted blood glucose level and plasma insulin level, even leaded to insulin resistance in adult mice. • BPA treatment decreased the insulin signaling, AKT, GSK3β and ERK phosphorylation in CNS. • BPA treatment impaired glucose uptake by decreasing GLUTs expression in CNS.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.01.017