Effects of ampicillin, cefazolin and cefoperazone treatments on GLT-1 expressions in the mesocorticolimbic system and ethanol intake in alcohol-preferring rats
Highlights • Ampicillin, cefazolin and cefoperazone treatments reduced alcohol intake. • These drugs upregulated both GLT-1 and pAKT levels in the NAc and PFC. • Cefoperazone significantly inhibited hepatic ALDH2. • Ampicillin, cefazolin and cefoperazone have been found in CSF.
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Veröffentlicht in: | Neuroscience 2015-06, Vol.295, p.164-174 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • Ampicillin, cefazolin and cefoperazone treatments reduced alcohol intake. • These drugs upregulated both GLT-1 and pAKT levels in the NAc and PFC. • Cefoperazone significantly inhibited hepatic ALDH2. • Ampicillin, cefazolin and cefoperazone have been found in CSF. |
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ISSN: | 0306-4522 1873-7544 |
DOI: | 10.1016/j.neuroscience.2015.03.038 |