Effects of ampicillin, cefazolin and cefoperazone treatments on GLT-1 expressions in the mesocorticolimbic system and ethanol intake in alcohol-preferring rats

Highlights • Ampicillin, cefazolin and cefoperazone treatments reduced alcohol intake. • These drugs upregulated both GLT-1 and pAKT levels in the NAc and PFC. • Cefoperazone significantly inhibited hepatic ALDH2. • Ampicillin, cefazolin and cefoperazone have been found in CSF.

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Veröffentlicht in:Neuroscience 2015-06, Vol.295, p.164-174
Hauptverfasser: Rao, P.S.S, Goodwani, S, Bell, R.L, Wei, Y, Boddu, S.H.S, Sari, Y
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • Ampicillin, cefazolin and cefoperazone treatments reduced alcohol intake. • These drugs upregulated both GLT-1 and pAKT levels in the NAc and PFC. • Cefoperazone significantly inhibited hepatic ALDH2. • Ampicillin, cefazolin and cefoperazone have been found in CSF.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.03.038