PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma
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| Veröffentlicht in: | Leukemia 2015-10, Vol.29 (10), p.2110-2113 |
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| creator | Paiva, B Azpilikueta, A Puig, N Ocio, E M Sharma, R Oyajobi, B O Labiano, S San-Segundo, L Rodriguez, A Aires-Mejia, I Rodriguez, I Escalante, F de Coca, A G Barez, A San Miguel, J F Melero, I |
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| doi_str_mv | 10.1038/leu.2015.79 |
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metabolism ; Killer Cells, Natural - pathology ; letter-to-the-editor ; Medicine ; Medicine & Public Health ; Membrane proteins ; Methods ; Mice ; Mice, Inbred C57BL ; Multiple myeloma ; Multiple Myeloma - metabolism ; Multiple Myeloma - mortality ; Multiple Myeloma - pathology ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Neoplasm, Residual - metabolism ; Neoplasm, Residual - mortality ; Neoplasm, Residual - pathology ; Oncology ; PD-1 protein ; PD-L1 protein ; Prognosis ; Programmed Cell Death 1 Receptor - antagonists & inhibitors ; Programmed Cell Death 1 Receptor - metabolism ; Prospective Studies ; Stem Cells - metabolism ; Stem Cells - pathology ; Survival Rate ; T-Lymphocytes - metabolism ; T-Lymphocytes - pathology ; Tumor Microenvironment</subject><ispartof>Leukemia, 2015-10, Vol.29 (10), p.2110-2113</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c680t-5f233e835433511e930f3576b70766a56bdeae3fd603af3d99c585432ced95903</citedby><cites>FETCH-LOGICAL-c680t-5f233e835433511e930f3576b70766a56bdeae3fd603af3d99c585432ced95903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2015.79$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2015.79$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25778100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paiva, B</creatorcontrib><creatorcontrib>Azpilikueta, A</creatorcontrib><creatorcontrib>Puig, N</creatorcontrib><creatorcontrib>Ocio, E M</creatorcontrib><creatorcontrib>Sharma, R</creatorcontrib><creatorcontrib>Oyajobi, B O</creatorcontrib><creatorcontrib>Labiano, S</creatorcontrib><creatorcontrib>San-Segundo, L</creatorcontrib><creatorcontrib>Rodriguez, A</creatorcontrib><creatorcontrib>Aires-Mejia, I</creatorcontrib><creatorcontrib>Rodriguez, I</creatorcontrib><creatorcontrib>Escalante, F</creatorcontrib><creatorcontrib>de Coca, A G</creatorcontrib><creatorcontrib>Barez, A</creatorcontrib><creatorcontrib>San Miguel, J F</creatorcontrib><creatorcontrib>Melero, I</creatorcontrib><title>PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><subject>13/31</subject><subject>631/67/1059/2325</subject><subject>631/67/1990/804</subject><subject>631/80/86</subject><subject>692/699/67/327</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>B7-H1 Antigen - metabolism</subject><subject>Bone Marrow - metabolism</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Cells, Cultured</subject><subject>Critical Care Medicine</subject><subject>Development and progression</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Immunophenotyping</subject><subject>Immunotherapy</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Killer Cells, Natural - pathology</subject><subject>letter-to-the-editor</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane proteins</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - metabolism</subject><subject>Multiple Myeloma - mortality</subject><subject>Multiple Myeloma - pathology</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Neoplasm, Residual - metabolism</subject><subject>Neoplasm, Residual - mortality</subject><subject>Neoplasm, Residual - pathology</subject><subject>Oncology</subject><subject>PD-1 protein</subject><subject>PD-L1 protein</subject><subject>Prognosis</subject><subject>Programmed Cell Death 1 Receptor - antagonists & inhibitors</subject><subject>Programmed Cell Death 1 Receptor - metabolism</subject><subject>Prospective Studies</subject><subject>Stem Cells - metabolism</subject><subject>Stem Cells - pathology</subject><subject>Survival Rate</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - pathology</subject><subject>Tumor Microenvironment</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkttrFDEUxgdR7Fp98l0GhCLobHNP5nGpV1jQB30O2Zkz3dRMsiaZwv73ZrpVVykqgQRyft-5JF9VPcVoiRFV5w6mJUGYL2V7r1pgJkXDOcf3qwVSSjaiJeykepTSFUJzUDysTgiXUmGEFlX36XWzxudlx_UuQgLfQW19nbdQ52kMsR5tFwP4axuDH8Hn2vi-Nl221zbv6zDUN9qNC91X099ox8llu3NQj3twYTSPqweDcQme3J6n1Ze3bz5fvG_WH999uFitm04olBs-EEpBUc4o5RhDS9FAuRQbiUrXhotNDwbo0AtEzUD7tu24KjDpoG95i-hp9eKQdxfDtwlS1qNNHThnPIQpaSwpUURwpv4DJYhxIhQv6PM_0KswRV8G0aVfLBhCCv2NwhK3jFDE2C_q0jjQ1g8hR9PNpfWKUawoZoIUankHVVYP5TOCh8GW-98EZ0eCLRiXtym4Kdvgk14JjMhcXf4LPM748gCWv08pwqB30Y4m7jVGenadLq7Ts-u0bAv97Hb4aTNC_5P9YbMCvDoAqYT8JcSj17kj33dFx9m_</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Paiva, B</creator><creator>Azpilikueta, A</creator><creator>Puig, N</creator><creator>Ocio, E M</creator><creator>Sharma, R</creator><creator>Oyajobi, B O</creator><creator>Labiano, S</creator><creator>San-Segundo, L</creator><creator>Rodriguez, A</creator><creator>Aires-Mejia, I</creator><creator>Rodriguez, I</creator><creator>Escalante, F</creator><creator>de Coca, A G</creator><creator>Barez, A</creator><creator>San Miguel, J F</creator><creator>Melero, I</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma</title><author>Paiva, B ; Azpilikueta, A ; Puig, N ; Ocio, E M ; Sharma, R ; Oyajobi, B O ; Labiano, S ; San-Segundo, L ; Rodriguez, A ; Aires-Mejia, I ; Rodriguez, I ; Escalante, F ; de Coca, A G ; Barez, A ; San Miguel, J F ; Melero, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c680t-5f233e835433511e930f3576b70766a56bdeae3fd603af3d99c585432ced95903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13/31</topic><topic>631/67/1059/2325</topic><topic>631/67/1990/804</topic><topic>631/80/86</topic><topic>692/699/67/327</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>B7-H1 Antigen - 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mortality</topic><topic>Multiple Myeloma - pathology</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Neoplasm, Residual - metabolism</topic><topic>Neoplasm, Residual - mortality</topic><topic>Neoplasm, Residual - pathology</topic><topic>Oncology</topic><topic>PD-1 protein</topic><topic>PD-L1 protein</topic><topic>Prognosis</topic><topic>Programmed Cell Death 1 Receptor - antagonists & inhibitors</topic><topic>Programmed Cell Death 1 Receptor - metabolism</topic><topic>Prospective Studies</topic><topic>Stem Cells - metabolism</topic><topic>Stem Cells - pathology</topic><topic>Survival Rate</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes - pathology</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paiva, B</creatorcontrib><creatorcontrib>Azpilikueta, A</creatorcontrib><creatorcontrib>Puig, N</creatorcontrib><creatorcontrib>Ocio, E M</creatorcontrib><creatorcontrib>Sharma, R</creatorcontrib><creatorcontrib>Oyajobi, B O</creatorcontrib><creatorcontrib>Labiano, S</creatorcontrib><creatorcontrib>San-Segundo, L</creatorcontrib><creatorcontrib>Rodriguez, A</creatorcontrib><creatorcontrib>Aires-Mejia, I</creatorcontrib><creatorcontrib>Rodriguez, I</creatorcontrib><creatorcontrib>Escalante, F</creatorcontrib><creatorcontrib>de Coca, A G</creatorcontrib><creatorcontrib>Barez, A</creatorcontrib><creatorcontrib>San Miguel, J F</creatorcontrib><creatorcontrib>Melero, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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| ispartof | Leukemia, 2015-10, Vol.29 (10), p.2110-2113 |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | 13/31 631/67/1059/2325 631/67/1990/804 631/80/86 692/699/67/327 Animals Apoptosis B7-H1 Antigen - metabolism Bone Marrow - metabolism Cancer Research Case-Control Studies Cells, Cultured Critical Care Medicine Development and progression Drug therapy Female Follow-Up Studies Gene expression Genetic aspects Genotype Health aspects Hematology Humans Identification and classification Immunophenotyping Immunotherapy Intensive Internal Medicine Killer Cells, Natural - metabolism Killer Cells, Natural - pathology letter-to-the-editor Medicine Medicine & Public Health Membrane proteins Methods Mice Mice, Inbred C57BL Multiple myeloma Multiple Myeloma - metabolism Multiple Myeloma - mortality Multiple Myeloma - pathology Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Neoplasm, Residual - metabolism Neoplasm, Residual - mortality Neoplasm, Residual - pathology Oncology PD-1 protein PD-L1 protein Prognosis Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Prospective Studies Stem Cells - metabolism Stem Cells - pathology Survival Rate T-Lymphocytes - metabolism T-Lymphocytes - pathology Tumor Microenvironment |
| title | PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma |
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