Only humans have human placentas: molecular differences between mice and humans

Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserve...

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Veröffentlicht in:	Journal of reproductive immunology 2015-04, Vol.108, p.65-71
Hauptverfasser:	Schmidt, André, Morales-Prieto, Diana M, Pastuschek, Jana, Fröhlich, Karolin, Markert, Udo R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chorionic Gonadotropin - metabolism Female Human chorionic gonadotropin Humans Mice microRNA Models, Animal Mouse model Obstetrics and Gynecology Placenta Placenta - physiology Pregnancy Primates Species Specificity Trophoblast
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserved microRNAs show species-specific target repertoires.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2015.03.001