The effect of estrogen-related receptor α on the regulation of angiogenesis after spinal cord injury

Highlights • XCT790 was applied to the rat traumatic spinal cord injury model. • XCT790 significantly inhibited the expression of ERRα. • XCT790 significantly decreased in VEGF and Ang-2 expression. • XCT790 significantly decreased vascular density and endothelial cell proliferation. • ERRα was invo...

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Veröffentlicht in:	Neuroscience 2015-04, Vol.290, p.570-580
Hauptverfasser:	Hu, J.Z, Long, H, Wu, T.-D, Zhou, Y, Lu, H.-B
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Angiogenesis Inhibitors - pharmacology Angiopoietin-2 - metabolism Animals Cell Proliferation - drug effects Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - pathology Endothelial Cells - physiology ERRalpha Estrogen-Related Receptor estrogen receptor-related receptor-α Male Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Neovascularization, Pathologic - physiopathology Neurology Nitriles - pharmacology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Random Allocation Rats, Sprague-Dawley Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - metabolism Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology spinal cord injury Thiazoles - pharmacology Transcription Factors - metabolism Vascular Endothelial Growth Factor A - metabolism XCT790
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Zusammenfassung:	Highlights • XCT790 was applied to the rat traumatic spinal cord injury model. • XCT790 significantly inhibited the expression of ERRα. • XCT790 significantly decreased in VEGF and Ang-2 expression. • XCT790 significantly decreased vascular density and endothelial cell proliferation. • ERRα was involved in mediating angiogenesis in a rat traumatic SCI model.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.01.067