NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress

Highlights • PTZ-kindling up-regulates hippocampal NMDA receptor NR2B subunits expression. • NMDA receptor NR2B subunits contribute to PTZ-kindling-induced astrocytosis. • NMDA receptor NR2B subunits contribute to PTZ-kindling-induced oxidative stress. • NMDA receptor NR2B subunits contribute to PTZ...

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Veröffentlicht in:	Brain research bulletin 2015-05, Vol.114, p.70-78
Hauptverfasser:	Zhu, Xinjian, Dong, Jingde, Shen, Kai, Bai, Ying, Zhang, Yuan, Lv, Xuan, Chao, Jie, Yao, Honghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - pathology Astrocytes - physiology Astrocytosis BDNF Brain-Derived Neurotrophic Factor - metabolism Cell Death - drug effects Cell Death - physiology Epilepsy Epilepsy - metabolism Excitatory Amino Acid Antagonists - pharmacology Gliosis - drug therapy Gliosis - pathology Gliosis - physiopathology Glutathione Peroxidase - metabolism Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Kindling Kindling, Neurologic - drug effects Kindling, Neurologic - pathology Kindling, Neurologic - physiology Male Malondialdehyde - metabolism Mice, Inbred C57BL Neurology Neurons - drug effects Neurons - pathology Neurons - physiology NMDA receptor Oxidative Stress - drug effects Oxidative Stress - physiology Pentylenetetrazole Piperidines - pharmacology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Superoxide Dismutase - metabolism
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Zusammenfassung:	Highlights • PTZ-kindling up-regulates hippocampal NMDA receptor NR2B subunits expression. • NMDA receptor NR2B subunits contribute to PTZ-kindling-induced astrocytosis. • NMDA receptor NR2B subunits contribute to PTZ-kindling-induced oxidative stress. • NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal neuron loss. • NMDA receptor NR2B subunits contribute to PTZ-kindling-induced BDNF expression in hippocampus.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.04.002