Synthesis and dose interval dependent hepatotoxicity evaluation of intravenously administered polyethylene glycol-8000 coated ultra-small superparamagnetic iron oxide nanoparticle on Wistar rats

Highlights • Synthesized PUSPIOs showed excellent hemocompatibility and biocompatibility. • Dose dependent hepatotoxicity of PUSPIOs was studied by biochemical assays. • Results illuminate better drug tolerance to the dose of 10 mg/kg b.w. per week. • Our results pave way for the use of PUSPIOs in b...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-03, Vol.39 (2), p.727-735
Hauptverfasser:	Rajan, Balan, Sathish, Shanmugam, Balakumar, Subramanian, Devaki, Thiruvengadam
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Alanine Transaminase - blood Alkaline Phosphatase - blood Animals Aspartate Aminotransferases - blood Biocompatibility Brain - anatomy & histology Brain - drug effects Catalase - metabolism Emergency Ferrosoferric Oxide - chemistry Ferrosoferric Oxide - toxicity gamma-Glutamyltransferase - blood Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Heart - anatomy & histology Heart - drug effects Hemo-compatibility Hepatotoxicity Kidney - anatomy & histology Kidney - drug effects Liver - anatomy & histology Liver - drug effects Liver - metabolism Lung - anatomy & histology Lung - drug effects Magnetic nanoparticles Magnetic Phenomena Male Microscopy, Electron, Transmission Nanoparticles - chemistry Nanoparticles - toxicity Nanoparticles - ultrastructure Nanotoxicity Polyethylene glycol Polyethylene Glycols - chemistry Rats, Wistar Spectroscopy, Fourier Transform Infrared Spleen - anatomy & histology Spleen - drug effects Superoxide Dismutase - metabolism
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Zusammenfassung:	Highlights • Synthesized PUSPIOs showed excellent hemocompatibility and biocompatibility. • Dose dependent hepatotoxicity of PUSPIOs was studied by biochemical assays. • Results illuminate better drug tolerance to the dose of 10 mg/kg b.w. per week. • Our results pave way for the use of PUSPIOs in bio-medical application.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.01.018