Association of SPP1 promoter variants with hip osteoarthritis susceptibility in Chinese population

Three genetic variants in the promoter of SPP1 (secreted phosphoprotein 1) gene have been reported to affect transcriptional activity of SPP1, thus conferring an increased risk for some diseases. To testify if these variants are associated with risk of hip osteoarthritis (OA) as well, we performed a...

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Veröffentlicht in:	Gene 2015-06, Vol.564 (1), p.9-13
Hauptverfasser:	Lv, Chuanjian, Li, Yan, Xu, Junling, Cao, Huichun, Li, Xiaoxiao, Ma, Bo, Ning, Peigang, Wang, Yan, Wang, Meiyun, Zhu, Shaocheng, Ge, Yinghui, Huang, Suizhu, Jin, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Case-Control Studies China Female Gene Expression Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genetic variant Hip osteoarthritis Humans Male Middle Aged Osteoarthritis, Hip - genetics Osteoarthritis, Hip - metabolism Osteopontin - genetics Osteopontin - metabolism Polymorphism, Single Nucleotide Promoter Regions, Genetic Risk Factors SPP1
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Zusammenfassung:	Three genetic variants in the promoter of SPP1 (secreted phosphoprotein 1) gene have been reported to affect transcriptional activity of SPP1, thus conferring an increased risk for some diseases. To testify if these variants are associated with risk of hip osteoarthritis (OA) as well, we performed a case–control study including 389 hip OA patients and 315 healthy controls. Genotypes of SPP1 were determined by DNA sequencing, and differential expressions of SPP1 in relation with genotypes were evaluated by RT-PCR and ELISA. The results showed that rs17524488 (delG>insG) increased the risk of hip OA, with the adjusted OR 1.48 (95% CI 1.18–1.85, P
ISSN:	0378-1119 1879-0038
DOI:	10.1016/j.gene.2015.03.036