Toxicity of the insecticide chlorpyrifos to the South American toad Rhinella arenarum at larval developmental stage

Highlights • Rhinella arenarum is exposed to relevant pesticide amounts during the reproductive season. • Chlorpyrifos is teratogenic and causes lethal effects on R. arenarum larvae at ppm range. • Esterases are early inhibited by sublethal (1/10 LC50) chlorpyrifos levels. • Sublethal chlorpyrifos c...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-03, Vol.39 (2), p.525-535
Hauptverfasser:	Liendro, Natacha, Ferrari, Ana, Mardirosian, Mariana, Lascano, Cecilia I, Venturino, Andrés
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibia Amphibian Proteins - metabolism Amphibians Animals Biomarkers Bufonidae - growth & development Bufonidae - metabolism Carboxylesterase - metabolism Catalase - metabolism Chlorpyrifos - toxicity Cholinesterase inhibition Cholinesterases - metabolism Emergency Glutathione - metabolism Glutathione Transferase - metabolism Insecticides - toxicity Larva - drug effects Larva - growth & development Larva - metabolism Lethal Dose 50 No-Observed-Adverse-Effect Level Organophosphates Oxidative stress
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Beschreibung
Zusammenfassung:	Highlights • Rhinella arenarum is exposed to relevant pesticide amounts during the reproductive season. • Chlorpyrifos is teratogenic and causes lethal effects on R. arenarum larvae at ppm range. • Esterases are early inhibited by sublethal (1/10 LC50) chlorpyrifos levels. • Sublethal chlorpyrifos concentrations also cause oxidative stress and antioxidant response. • Environmental chlorpyrifos concentrations may compromise tadpole progression.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.12.022