Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia

Dual-specificity phosphatases (DUSPs) show distinct substrate preferences for specific MAPKs. DUSPs sharing a substrate preference for ERK1/2 may be classified as inducible or constitutive. In contrast to the inducible DUSPs which also dephosphorylate p38 MAPK and JNK in the major inflammatory pathw...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-11, Vol.467 (2), p.254-260
Hauptverfasser:	Ham, Ji-Eun, Oh, Eun-Kyung, Kim, Dong-Hoon, Choi, Sang-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn BCI Dual Specificity Phosphatase 1 - antagonists & inhibitors Dual Specificity Phosphatase 1 - genetics Dual Specificity Phosphatase 1 - metabolism Dual Specificity Phosphatase 6 - antagonists & inhibitors Dual Specificity Phosphatase 6 - genetics Dual Specificity Phosphatase 6 - metabolism DUSP6 DUSP7 Flavonoids - pharmacology FR180204 Gene Expression Regulation Isoenzymes - genetics Isoenzymes - metabolism Lipopolysaccharides - pharmacology Microglia Microglia - cytology Microglia - drug effects Microglia - metabolism Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism PD98059 Phosphorylation - drug effects Primary Cell Culture Protein Kinase Inhibitors - pharmacology Pyrazoles - pharmacology Pyridazines - pharmacology Rats Rats, Sprague-Dawley Signal Transduction
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