Increased risk of non-AIDS-related events in HIV subjects with persistent low CD4 counts despite cART in the CoRIS cohort

•We explored clinical complications of HIV subjects with persistent low CD4 despite virological suppression under cART.•The persistence of low CD4 despite long-term virological suppression do not imply an increased risk of AIDS-defining events.•We found a greater risk for non-AIDS-defining diseases, contrasting with findings of the previous report. The aim was to analyze clinical complications in HIV-infected subjects who persistently maintain low CD4 levels despite virological response to cART in the Spanish CoRIS cohort. The main inclusion criteria were CD4 counts